Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro

Pimecrolimus (Elidel, SDZ ASM 981) is an anti-inflammatory and immunomodulatory 33-epichloro-derivative of macrolactam ascomycin, with low potential for affecting systemic immune responses compared with other calcineurin inhibitors, cyclosporin A and tacrolimus. Despite numerous studies focused on t...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142953-e0142953
Hauptverfasser:	Heneberg, Petr, Riegerová, Kamila, Kučera, Petr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergens - immunology Allergic diseases Allergic reactions Allergies Anaphylaxis Animals Anti-Allergic Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibodies, Anti-Idiotypic - immunology Apis mellifera Asthma Basophils - drug effects Basophils - immunology Bees - immunology Betula - immunology Calcineurin Calcineurin inhibitors CD45 antigen CD63 antigen Cells, Cultured Cyclosporin A Cytometry Dermatitis Flow cytometry Humans Hypersensitivity Hypersensitivity - drug therapy Hypersensitivity - immunology Immune response Immunoglobulin E Immunoglobulin E - immunology Immunology Immunomodulation Inflammation Inhibition Leukocytes (basophilic) Mast cells Medicine Middle Aged Patients Pollen Population Pretreatment Receptors, IgE - immunology Rhinitis, Allergic, Seasonal - drug therapy Rhinitis, Allergic, Seasonal - immunology Tacrolimus Tacrolimus - analogs & derivatives Tacrolimus - pharmacology Venom Wasp Venoms - immunology Wasps - immunology Young Adult
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