LPS-Stimulated Human Skin-Derived Stem Cells Enhance Neo-Vascularization during Dermal Regeneration

High numbers of adult stem cells are still required to improve the formation of new vessels in scaffolds to accelerate dermal regeneration. Recent data indicate a benefit for vascularization capacity by stimulating stem cells with lipopolysaccharide (LPS). In this study, stem cells derived from huma...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142907-e0142907
Hauptverfasser:	Kisch, Tobias, Weber, Caroline, Rapoport, Daniel H, Kruse, Charli, Schumann, Sandra, Stang, Felix H, Siemers, Frank, Matthießen, Anna E
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Biopsy Biotechnology Blood vessels Cell Culture Techniques Cell Differentiation Cells, Cultured Collagen - chemistry Comparative analysis Culture Media, Conditioned - chemistry Cytokines Hand surgery Humans Inflammation Ischemia Laboratory animals Life assessment Lipopolysaccharides Lipopolysaccharides - chemistry Mesenchymal stem cells Mice Mice, Nude Morphogenesis Neovascularization, Physiologic Physiological aspects Physiology Plastic surgery Regeneration Regeneration - physiology Scaffolds Secretion Skin Skin & tissue grafts Skin - blood supply Skin - cytology Skin - pathology Skin Physiological Phenomena Skin, Artificial Stem cells Stem Cells - cytology Substitutes Tissue engineering Tissue Engineering - methods Tissue Scaffolds Vascular endothelial growth factor Vascularization Wound Healing
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