Blood Biomarkers Associated with Cognitive Decline in Early Stage and Drug-Naive Parkinson's Disease Patients

Early diagnosis of Parkinson's disease (PD) continues to be a major challenge in the field. The lack of a robust biomarker to detect early stage PD patients has considerably slowed the progress toward the development of potential therapeutic agents. We have previously evaluated several RNA biom...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142582-e0142582
Hauptverfasser:	Santiago, Jose A, Potashkin, Judith A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antiparkinson agents Bioindicators Biological markers Biomarkers Biomarkers - blood Blood Chemical compounds Coatomer Protein - genetics Cognition Cognitive ability Cognitive Dysfunction - blood Cognitive Dysfunction - complications Cognitive Dysfunction - diagnosis Cognitive Dysfunction - genetics Correlation analysis Cross-Sectional Studies Diabetes Diabetes mellitus Dopamine Dosage and administration Epidermal growth factor Female Glucose Glucose metabolism Health aspects Heterogeneous-Nuclear Ribonucleoproteins - genetics Humans Insulin Insulin-like growth factors Longitudinal Studies Male Medicine Metabolism Middle Aged Movement disorders Neurodegenerative diseases Parkinson Disease - blood Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson Disease - genetics Parkinson's disease Patients Peptide Elongation Factors - genetics Pharmacology Polymerase chain reaction Polypyrimidine Tract-Binding Protein - genetics Prediabetic state Ribonucleic acid Ribonucleoprotein, U5 Small Nuclear - genetics RNA RNA, Messenger - blood RNA, Messenger - genetics Studies
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