The Distinct Gene Regulatory Network of Myoglobin in Prostate and Breast Cancer

Myoglobin (MB) is not only strongly expressed in myocytes, but also at much lower levels in different cancer entities. 40% of breast tumors are MB-positive, with the globin being co-expressed with markers of tumor hypoxia in a proportion of cases. In breast cancer, MB expression is associated with a...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142662-e0142662
Hauptverfasser:	Bicker, Anne, Brahmer, Alexandra M, Meller, Sebastian, Kristiansen, Glen, Gorr, Thomas A, Hankeln, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Binding Sites Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cancer genetics Cell Hypoxia Cell Line, Tumor Chromatin - metabolism Colorectal cancer Computational Biology Data Mining Data processing Epigenesis, Genetic Epigenetic inheritance Estrogens Female Gene expression Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genes Genes, Regulator Genes, Reporter Humans Hypoxia Lung cancer Male Medical prognosis Muscles Musculoskeletal system Myocytes Myoglobin Myoglobin - genetics Myoglobin - metabolism Myoglobins Prognosis Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proteins Reverse Transcriptase Polymerase Chain Reaction Smooth muscle Transcription Transcription (Genetics) Tumors
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