Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma

Nucleolar and spindle-associated protein 1 (NUSAP1) is an important mitotic regulator. In addition to its crucial function in mitosis, NUSAP1 has recently received attention due to the interesting roles in carcinogenesis. The aim of this study was to reveal functional mechanisms of NUSAP1 in oral sq...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142252
Hauptverfasser:	Okamoto, Atsushi, Higo, Morihiro, Shiiba, Masashi, Nakashima, Dai, Koyama, Tomoyoshi, Miyamoto, Isao, Kasama, Hiroki, Kasamatsu, Atsushi, Ogawara, Katsunori, Yokoe, Hidetaka, Tanzawa, Hideki, Uzawa, Katsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Apoptosis - drug effects Apoptosis - genetics Biomarkers Biomarkers, Tumor - genetics Breast cancer Carcinogenesis Carcinogens Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell cycle Cell Cycle - drug effects Cell Cycle - genetics Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Cellular proteins Chromosomes Correlation analysis Dentistry Down-Regulation Drug therapy Gene expression Gene Expression Regulation, Neoplastic Health aspects Hospitals Humans Immunoblotting Immunohistochemistry Keratinocytes Kinases Laboratories Liver cancer Maxillofacial surgery Medicine Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitosis Mouth cancer Mouth Neoplasms - drug therapy Mouth Neoplasms - genetics Mouth Neoplasms - pathology Nucleoli Oral cancer Oral squamous cell carcinoma Paclitaxel Paclitaxel - pharmacology Paclitaxel - therapeutic use Penicillin Phase transitions Physiological aspects Polymerase chain reaction Proteins Ribonucleic acid RNA RNA-directed DNA polymerase Science Squamous cell carcinoma Surgery Tumors
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