p21WAF1 Is Required for Interleukin-16-Induced Migration and Invasion of Vascular Smooth Muscle Cells via the p38MAPK/Sp-1/MMP-9 Pathway

Interleukin-16 (IL-16) is a lymphocyte chemoattractant factor well known for its role in immune responses, but its role in vascular disease is unknown. Here, we explored the novel physiological function of IL-16 in vascular smooth muscle cells (VSMCs). The expression of IL-16 and its receptor CD4 wa...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142153-e0142153
Hauptverfasser:	Park, Sung Lyea, Hwang, Byungdoo, Lee, Sun-Young, Kim, Won Tae, Choi, Yung Hyun, Chang, Young-Chae, Kim, Wun-Jae, Moon, Sung-Kwon
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Activator protein 1 Animals Arteriosclerosis Atherosclerosis Binding Blockage CD4 antigen CD4 Antigens - metabolism Cell adhesion & migration Cell Movement - drug effects Cell Movement - physiology Cell Proliferation Cells, Cultured Complications and side effects Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-dependent kinases Development and progression Gelatinase B Imidazoles - pharmacology Immune response Inhibitors Interleukin 16 Interleukin-16 - metabolism Interleukin-16 - pharmacology Interleukins Kinases Leukocyte migration Lymphocytes MAP Kinase Signaling System Matrix Metalloproteinase 9 - metabolism Medical treatment Muscles Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - immunology Myocytes, Smooth Muscle - physiology NF-κB protein Nutrition p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Patient outcomes Phosphorylation Physiological aspects Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Rats Regulators RNA, Small Interfering - genetics Signaling siRNA Smooth muscle Sp1 Transcription Factor - metabolism Stenosis Transcription factors Vascular diseases
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