Resting-State fMRI Functional Connectivity Is Associated with Sleepiness, Imagery, and Discontinuity of Mind
Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to investigate the functional architecture of the healthy human brain and how it is affected by learning, lifelong development, brain disorders or pharmacological intervention. Non-sensory experiences are prevalent during r...
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| creator | Stoffers, Diederick Diaz, B Alexander Chen, Gang den Braber, Anouk van 't Ent, Dennis Boomsma, Dorret I Mansvelder, Huibert D de Geus, Eco Van Someren, Eus J W Linkenkaer-Hansen, Klaus |
| description | Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to investigate the functional architecture of the healthy human brain and how it is affected by learning, lifelong development, brain disorders or pharmacological intervention. Non-sensory experiences are prevalent during rest and must arise from ongoing brain activity, yet little is known about this relationship. Here, we used two runs of rs-fMRI both immediately followed by the Amsterdam Resting-State Questionnaire (ARSQ) to investigate the relationship between functional connectivity within ten large-scale functional brain networks and ten dimensions of thoughts and feelings experienced during the scan in 106 healthy participants. We identified 11 positive associations between brain-network functional connectivity and ARSQ dimensions. 'Sleepiness' exhibited significant associations with functional connectivity within Visual, Sensorimotor and Default Mode networks. Similar associations were observed for 'Visual Thought' and 'Discontinuity of Mind', which may relate to variation in imagery and thought control mediated by arousal fluctuations. Our findings show that self-reports of thoughts and feelings experienced during a rs-fMRI scan help understand the functional significance of variations in functional connectivity, which should be of special relevance to clinical studies. |
| doi_str_mv | 10.1371/journal.pone.0142014 |
| format | Article |
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Our findings show that self-reports of thoughts and feelings experienced during a rs-fMRI scan help understand the functional significance of variations in functional connectivity, which should be of special relevance to clinical studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0142014</identifier><identifier>PMID: 26540239</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alzheimer's disease ; Alzheimers disease ; Arousal ; Brain ; Brain - physiology ; Brain architecture ; Brain mapping ; Brain Mapping - methods ; Brain research ; Cognition & reasoning ; Discontinuity ; Education ; Female ; Functional magnetic resonance imaging ; Humans ; Image Processing, Computer-Assisted - methods ; Imagery (Psychotherapy) - methods ; Learning - physiology ; Magnetic resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Nerve Net - physiology ; Neural networks ; Neural Pathways - physiology ; Neurodevelopmental disorders ; Neuroimaging ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Pharmacology ; Rest - physiology ; Sensorimotor system ; Sleep and wakefulness ; Sleep Stages - physiology ; Sleepiness ; Variation ; Visual observation ; Young Adult</subject><ispartof>PloS one, 2015-11, Vol.10 (11), p.e0142014-e0142014</ispartof><rights>2015 Stoffers et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Stoffers et al 2015 Stoffers et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-7aa25dc9bd594068b03e2da1ae7a5a1862660e7db7f92f1360f7a34bfe2c510c3</citedby><cites>FETCH-LOGICAL-c577t-7aa25dc9bd594068b03e2da1ae7a5a1862660e7db7f92f1360f7a34bfe2c510c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634926/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634926/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26540239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoffers, Diederick</creatorcontrib><creatorcontrib>Diaz, B Alexander</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>den Braber, Anouk</creatorcontrib><creatorcontrib>van 't Ent, Dennis</creatorcontrib><creatorcontrib>Boomsma, Dorret I</creatorcontrib><creatorcontrib>Mansvelder, Huibert D</creatorcontrib><creatorcontrib>de Geus, Eco</creatorcontrib><creatorcontrib>Van Someren, Eus J W</creatorcontrib><creatorcontrib>Linkenkaer-Hansen, Klaus</creatorcontrib><title>Resting-State fMRI Functional Connectivity Is Associated with Sleepiness, Imagery, and Discontinuity of Mind</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to investigate the functional architecture of the healthy human brain and how it is affected by learning, lifelong development, brain disorders or pharmacological intervention. 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Non-sensory experiences are prevalent during rest and must arise from ongoing brain activity, yet little is known about this relationship. Here, we used two runs of rs-fMRI both immediately followed by the Amsterdam Resting-State Questionnaire (ARSQ) to investigate the relationship between functional connectivity within ten large-scale functional brain networks and ten dimensions of thoughts and feelings experienced during the scan in 106 healthy participants. We identified 11 positive associations between brain-network functional connectivity and ARSQ dimensions. 'Sleepiness' exhibited significant associations with functional connectivity within Visual, Sensorimotor and Default Mode networks. Similar associations were observed for 'Visual Thought' and 'Discontinuity of Mind', which may relate to variation in imagery and thought control mediated by arousal fluctuations. 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| subjects | Adult Alzheimer's disease Alzheimers disease Arousal Brain Brain - physiology Brain architecture Brain mapping Brain Mapping - methods Brain research Cognition & reasoning Discontinuity Education Female Functional magnetic resonance imaging Humans Image Processing, Computer-Assisted - methods Imagery (Psychotherapy) - methods Learning - physiology Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Nerve Net - physiology Neural networks Neural Pathways - physiology Neurodevelopmental disorders Neuroimaging Neurosciences NMR Nuclear magnetic resonance Pharmacology Rest - physiology Sensorimotor system Sleep and wakefulness Sleep Stages - physiology Sleepiness Variation Visual observation Young Adult |
| title | Resting-State fMRI Functional Connectivity Is Associated with Sleepiness, Imagery, and Discontinuity of Mind |
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