Regulation of Guinea Pig Detrusor Smooth Muscle Excitability by 17β-Estradiol: The Role of the Large Conductance Voltage- and Ca2+-Activated K+ Channels

Estrogen replacement therapies have been suggested to be beneficial in alleviating symptoms of overactive bladder. However, the precise regulatory mechanisms of estrogen in urinary bladder smooth muscle (UBSM) at the cellular level remain unknown. Large conductance voltage- and Ca2+-activated K+ (BK...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0141950-e0141950
Hauptverfasser:	Provence, Aaron, Hristov, Kiril L, Parajuli, Shankar P, Petkov, Georgi V
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Bladder Calcium channels Calcium channels (L-type) Calcium channels (voltage-gated) Calcium Channels, L-Type - chemistry Calcium Channels, L-Type - metabolism Calcium conductance Calcium ions Cells, Cultured Channel gating Channel opening Channels Conductance Depolarization Electric potential Estradiol Estradiol - pharmacology Estrogen Estrogens Excitability Guinea Pigs Hormone replacement therapy Hyperpolarization Indoles - pharmacology Kinases Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors Large-Conductance Calcium-Activated Potassium Channels - metabolism Male Membrane potential Membrane Potentials - drug effects Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscles Ostomy Patch-Clamp Techniques Pharmacy Physiology Potassium Potassium Channel Blockers - pharmacology Potassium channels (calcium-gated) Proteins Regulators Regulatory mechanisms (biology) Resistance Rodents Sex hormones Smooth muscle Studies Urinary bladder Urinary Bladder - cytology
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