Tetrazine-Containing Amino Acid for Peptide Modification and Live Cell Labeling

A novel amino acid derivative 3-(4-(1, 2, 4, 5-tetrazine-3-yl) phenyl)-2-aminopropanoic acid was synthesized in this study. The compound possessed better water-solubility and was synthesized more easily compared with the well-known and commercially available 3-(p-benzylamino)-1, 2, 4, 5-tetrazine. T...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0141918-e0141918
Hauptverfasser:	Ni, Zhongqiu, Zhou, Lanxia, Li, Xu, Zhang, Jing, Dong, Shouliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino acids Amino Acids - chemistry Animals Biochemistry Biological activity Biological markers Cancer Chromatography Comparative analysis Experiments Heterocyclic Compounds, 1-Ring - chemistry Heterocyclic Compounds, 1-Ring - pharmacokinetics Humans Intestines - metabolism Labeling Labelling Laboratories Life sciences Ligands Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mice Molecular biology NMR Nuclear magnetic resonance Peptide Fragments - chemistry Peptide synthesis Peptides Phenylalanine Phenylalanine - analogs & derivatives Phenylalanine - chemistry Phenylalanine - pharmacokinetics Proteins Smooth muscle Solubility Synthesis Technology application Tissue Distribution Tumor Cells, Cultured Tyrosine
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