Inhibitory Effects of KP-A159, a Thiazolopyridine Derivative, on Osteoclast Differentiation, Function, and Inflammatory Bone Loss via Suppression of RANKL-Induced MAP Kinase Signaling Pathway

Abnormally elevated formation and activation of osteoclasts are primary causes for a majority of skeletal diseases. In this study, we found that KP-A159, a newly synthesized thiazolopyridine derivative, inhibited osteoclast differentiation and function in vitro, and inflammatory bone loss in vivo. K...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142201-e0142201
Hauptverfasser:	Ihn, Hye Jung, Lee, Doohyun, Lee, Taeho, Kim, Sang-Hyun, Shin, Hong-In, Bae, Yong Chul, Hong, Jung Min, Park, Eui Kyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance Actin Activation Analysis Animals Biocompatibility Biomedical materials Bone loss Bone marrow Bone resorption Bone Resorption - pathology c-Jun protein Cathepsin K Cell Differentiation Colony-stimulating factor Cytotoxicity Dendritic cells Dentistry Differentiation Extracellular signal-regulated kinase Gelatinase B Gene Expression Gene Expression Regulation Immunoglobulins Inflammation JNK protein Kinases Lipopolysaccharides Macrophage colony stimulating factor Macrophages MAP kinase MAP Kinase Signaling System Medicine Metalloproteinase Mice Mice, Inbred C57BL Muscle proteins Neurosciences Osteoclastogenesis Osteoclasts Osteoclasts - cytology Osteoclasts - drug effects Osteoporosis Pharmaceutical sciences Pharmacy Physiological aspects Protein kinase Proteins Pyridines - chemistry Pyridines - pharmacology RANK Ligand - metabolism RANK Ligand - physiology Signal transduction Signaling Thiazoles - chemistry Thiazoles - pharmacology TRANCE protein Transcription factors
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