Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance
We have developed novel stereoscopic wearable multimodal intraoperative imaging and display systems entitled Integrated Imaging Goggles for guiding surgeries. The prototype systems offer real time stereoscopic fluorescence imaging and color reflectance imaging capacity, along with in vivo handheld m...
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| Veröffentlicht in: | PloS one 2015-11, Vol.10 (11), p.e0141956-e0141956 |
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| creator | Mela, Christopher A Patterson, Carrie Thompson, William K Papay, Francis Liu, Yang |
| description | We have developed novel stereoscopic wearable multimodal intraoperative imaging and display systems entitled Integrated Imaging Goggles for guiding surgeries. The prototype systems offer real time stereoscopic fluorescence imaging and color reflectance imaging capacity, along with in vivo handheld microscopy and ultrasound imaging. With the Integrated Imaging Goggle, both wide-field fluorescence imaging and in vivo microscopy are provided. The real time ultrasound images can also be presented in the goggle display. Furthermore, real time goggle-to-goggle stereoscopic video sharing is demonstrated, which can greatly facilitate telemedicine. In this paper, the prototype systems are described, characterized and tested in surgeries in biological tissues ex vivo. We have found that the system can detect fluorescent targets with as low as 60 nM indocyanine green and can resolve structures down to 0.25 mm with large FOV stereoscopic imaging. The system has successfully guided simulated cancer surgeries in chicken. The Integrated Imaging Goggle is novel in 4 aspects: it is (a) the first wearable stereoscopic wide-field intraoperative fluorescence imaging and display system, (b) the first wearable system offering both large FOV and microscopic imaging simultaneously, |
| doi_str_mv | 10.1371/journal.pone.0141956 |
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The prototype systems offer real time stereoscopic fluorescence imaging and color reflectance imaging capacity, along with in vivo handheld microscopy and ultrasound imaging. With the Integrated Imaging Goggle, both wide-field fluorescence imaging and in vivo microscopy are provided. The real time ultrasound images can also be presented in the goggle display. Furthermore, real time goggle-to-goggle stereoscopic video sharing is demonstrated, which can greatly facilitate telemedicine. In this paper, the prototype systems are described, characterized and tested in surgeries in biological tissues ex vivo. We have found that the system can detect fluorescent targets with as low as 60 nM indocyanine green and can resolve structures down to 0.25 mm with large FOV stereoscopic imaging. The system has successfully guided simulated cancer surgeries in chicken. The Integrated Imaging Goggle is novel in 4 aspects: it is (a) the first wearable stereoscopic wide-field intraoperative fluorescence imaging and display system, (b) the first wearable system offering both large FOV and microscopic imaging simultaneously,</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0141956</identifier><identifier>PMID: 26529249</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Augmented reality ; Biomedical engineering ; Breast cancer ; Cancer ; CAT scans ; Chickens ; Depth Perception ; Editors ; Evaluation ; Fluorescence ; Goggles ; Humans ; Image Processing, Computer-Assisted - instrumentation ; Image Processing, Computer-Assisted - methods ; Imaging ; Lymphatic system ; Magnetic resonance imaging ; Medical imaging ; Microscopy ; Neoplasms - surgery ; Neoplasms - veterinary ; NMR ; Nuclear magnetic resonance ; Optics ; Poultry Diseases - surgery ; Real time ; Reflectance ; Sensors ; Stereoscopy ; Surgeons ; Surgery ; Surgery, Computer-Assisted - instrumentation ; Surgery, Computer-Assisted - methods ; Target detection ; Telemedicine ; Telemedicine - instrumentation ; Telemedicine - methods ; Tissues ; Ultrasonic imaging ; Ultrasound ; Ultrasound imaging ; Wearable technology</subject><ispartof>PloS one, 2015-11, Vol.10 (11), p.e0141956-e0141956</ispartof><rights>(c) the first wearable system that offers both ultrasound imaging and fluorescence imaging capacities, and (d) the first demonstration of goggle-to-goggle communication to share stereoscopic views for medical guidance.</rights><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”) Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b5c574e1ef27af9a3f8a47ba9bbc7e66f3905cff7023452465aa8e15fb4155d63</citedby><cites>FETCH-LOGICAL-c692t-b5c574e1ef27af9a3f8a47ba9bbc7e66f3905cff7023452465aa8e15fb4155d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631490/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631490/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26529249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Singhal, Sunil</contributor><creatorcontrib>Mela, Christopher A</creatorcontrib><creatorcontrib>Patterson, Carrie</creatorcontrib><creatorcontrib>Thompson, William K</creatorcontrib><creatorcontrib>Papay, Francis</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><title>Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We have developed novel stereoscopic wearable multimodal intraoperative imaging and display systems entitled Integrated Imaging Goggles for guiding surgeries. The prototype systems offer real time stereoscopic fluorescence imaging and color reflectance imaging capacity, along with in vivo handheld microscopy and ultrasound imaging. With the Integrated Imaging Goggle, both wide-field fluorescence imaging and in vivo microscopy are provided. The real time ultrasound images can also be presented in the goggle display. Furthermore, real time goggle-to-goggle stereoscopic video sharing is demonstrated, which can greatly facilitate telemedicine. In this paper, the prototype systems are described, characterized and tested in surgeries in biological tissues ex vivo. We have found that the system can detect fluorescent targets with as low as 60 nM indocyanine green and can resolve structures down to 0.25 mm with large FOV stereoscopic imaging. The system has successfully guided simulated cancer surgeries in chicken. The Integrated Imaging Goggle is novel in 4 aspects: it is (a) the first wearable stereoscopic wide-field intraoperative fluorescence imaging and display system, (b) the first wearable system offering both large FOV and microscopic imaging simultaneously,</description><subject>Animals</subject><subject>Augmented reality</subject><subject>Biomedical engineering</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>CAT scans</subject><subject>Chickens</subject><subject>Depth Perception</subject><subject>Editors</subject><subject>Evaluation</subject><subject>Fluorescence</subject><subject>Goggles</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - instrumentation</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Lymphatic system</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Microscopy</subject><subject>Neoplasms - surgery</subject><subject>Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mela, Christopher A</au><au>Patterson, Carrie</au><au>Thompson, William K</au><au>Papay, Francis</au><au>Liu, Yang</au><au>Singhal, Sunil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-11-03</date><risdate>2015</risdate><volume>10</volume><issue>11</issue><spage>e0141956</spage><epage>e0141956</epage><pages>e0141956-e0141956</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We have developed novel stereoscopic wearable multimodal intraoperative imaging and display systems entitled Integrated Imaging Goggles for guiding surgeries. The prototype systems offer real time stereoscopic fluorescence imaging and color reflectance imaging capacity, along with in vivo handheld microscopy and ultrasound imaging. With the Integrated Imaging Goggle, both wide-field fluorescence imaging and in vivo microscopy are provided. The real time ultrasound images can also be presented in the goggle display. Furthermore, real time goggle-to-goggle stereoscopic video sharing is demonstrated, which can greatly facilitate telemedicine. In this paper, the prototype systems are described, characterized and tested in surgeries in biological tissues ex vivo. We have found that the system can detect fluorescent targets with as low as 60 nM indocyanine green and can resolve structures down to 0.25 mm with large FOV stereoscopic imaging. The system has successfully guided simulated cancer surgeries in chicken. The Integrated Imaging Goggle is novel in 4 aspects: it is (a) the first wearable stereoscopic wide-field intraoperative fluorescence imaging and display system, (b) the first wearable system offering both large FOV and microscopic imaging simultaneously,</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26529249</pmid><doi>10.1371/journal.pone.0141956</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Augmented reality Biomedical engineering Breast cancer Cancer CAT scans Chickens Depth Perception Editors Evaluation Fluorescence Goggles Humans Image Processing, Computer-Assisted - instrumentation Image Processing, Computer-Assisted - methods Imaging Lymphatic system Magnetic resonance imaging Medical imaging Microscopy Neoplasms - surgery Neoplasms - veterinary NMR Nuclear magnetic resonance Optics Poultry Diseases - surgery Real time Reflectance Sensors Stereoscopy Surgeons Surgery Surgery, Computer-Assisted - instrumentation Surgery, Computer-Assisted - methods Target detection Telemedicine Telemedicine - instrumentation Telemedicine - methods Tissues Ultrasonic imaging Ultrasound Ultrasound imaging Wearable technology |
| title | Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance |
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