Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma

Ewing's sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease. Ewing's sarcoma cells are acutely hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibition and this is being evaluated in clinical trials, although the mecha...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140988
Hauptverfasser:	Gill, Sonja J, Travers, Jon, Pshenichnaya, Irina, Kogera, Fiona A, Barthorpe, Syd, Mironenko, Tatiana, Richardson, Laura, Benes, Cyril H, Stratton, Michael R, McDermott, Ultan, Jackson, Stephen P, Garnett, Mathew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Anticancer properties Apoptosis Apoptosis - drug effects Biochemistry Bone tumors Brain tumors BRCA1 protein Breast cancer Cancer therapies Cell growth Cell Line, Tumor Chemotherapy Clinical trials Cytotoxicity Dacarbazine - administration & dosage Dacarbazine - analogs & derivatives Damage accumulation Deoxyribonucleic acid DNA DNA biosynthesis DNA Breaks, Double-Stranded - drug effects DNA Breaks, Single-Stranded - drug effects DNA damage DNA Damage - drug effects DNA Damage - genetics DNA repair DNA Repair - genetics Double-strand break repair Ewings sarcoma Gene expression Glioma cells Homologous recombination Homologous Recombination - genetics Homology Humans Hypersensitivity Inhibition Inhibitors Kinases Life assessment Medical prognosis Medical research Melanoma Metastases Monosaccharides Mutation Patients Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage Poly(ADP-ribose) Polymerases - biosynthesis Prognosis Radiation therapy Repair Ribose Sarcoma Sarcoma, Ewing - drug therapy Sarcoma, Ewing - genetics Sarcoma, Ewing - pathology Sensitivity Targeted cancer therapy Temozolomide Trapping Tumors
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