A Potential Mechanism of High-Dose Ticagrelor in Modulating Platelet Activity and Atherosclerosis Mediated by Thymic Stromal Lymphopoietin Receptor

Abnormal expression of thymic stromal lymphopoietin (TSLP) and its receptor (TSLPR) was found in patients with acute coronary syndrome. Ticagrelor, an oral platelet ADP P2Y12 receptor antagonist, is widely used in these patients. The aim of this study was to verify whether different doses of ticagre...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0141464-e0141464
Hauptverfasser:	Mao, Yi, Peng, Yudong, Zeng, Qiutang, Cheng, Longxian, Wang, Boyuan, Mao, Xiaobo, Meng, Kai, Liu, Yuzhou, Lian, Yitian, Li, Dazhu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenosine - administration & dosage Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine diphosphate Agglomeration AKT protein AKT1 protein Animals Aorta - metabolism Aorta - pathology Apolipoprotein E Apolipoproteins Apolipoproteins E - deficiency Arteriosclerosis Atherosclerosis Atherosclerosis - blood Atherosclerosis - drug therapy Atherosclerosis - prevention & control Blood platelets Care and treatment CD63 antigen Cholesterol Cholesterol, Dietary - toxicity Complications and side effects Cytokines Cytokines - blood Cytokines - physiology Diet Dosage and administration Dose-Response Relationship, Drug Health aspects High cholesterol diet Hospitals Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - complications Hyperlipoproteinemia Type II - drug therapy Immunoglobulins - biosynthesis Immunoglobulins - drug effects Immunoglobulins - physiology Influence Kinases Lipids Lipids - blood Low density lipoprotein Mice Mice, Inbred C57BL Mice, Knockout Mortality P-Selectin - analysis Patients Phosphatidylinositol 3-Kinases - physiology Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - physiology Purinergic P2Y Receptor Antagonists - administration & dosage Purinergic P2Y Receptor Antagonists - pharmacology Random Allocation Receptors, Cytokine - biosynthesis Receptors, Cytokine - drug effects Receptors, Cytokine - physiology Rodents Science Signal transduction Signal Transduction - drug effects Tetraspanin 30 - blood Thrombosis Thymic stromal lymphopoietin Thymus Ticagrelor
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