Effects of PDE5 Inhibitors and sGC Stimulators in a Rat Model of Artificial Ureteral Calculosis

Urinary colics from calculosis are frequent and intense forms of pain whose current pharmacological treatment remains unsatisfactory. New and more effective drugs are needed to control symptoms and improve stone expulsion. Recent evidence suggested that the Nitric Oxide (NO) / cyclic guanosine monop...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0141477-e0141477
Hauptverfasser:	Sandner, Peter, Tinel, Hanna, Affaitati, Giannapia, Costantini, Raffaele, Giamberardino, Maria Adele
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Autopsy Behavior, Animal Cardiology Care and treatment Colic Cyclic GMP Cyclic Nucleotide Phosphodiesterases, Type 5 - chemistry Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Disease Models, Animal Drug therapy Enzyme Activators - administration & dosage Enzyme Activators - pharmacology Expulsion Female Gender differences Gene Expression Gene Expression Profiling Genetic aspects Guanosine Guanylate Cyclase - genetics Guanylate Cyclase - metabolism Health aspects Hyoscine Hyperalgesia Inhibitors Ketoprofen Laboratories Lithiasis - drug therapy Lithiasis - genetics Lithiasis - metabolism Lithiasis - pathology Lithotripsy Localization Male Muscle contraction Muscle Contraction - drug effects Muscles Nitric oxide Pain Pain perception Pharmacology Phosphodiesterase Phosphodiesterase 5 Inhibitors - administration & dosage Phosphodiesterase 5 Inhibitors - pharmacology R&D Rats Research & development RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Sildenafil Smooth muscle Stimulators Stone Ureter Ureter - drug effects Ureteral Calculi - drug therapy Ureteral Calculi - genetics Ureteral Calculi - metabolism Ureteral Calculi - pathology Ureteral diseases Urogenital system Urology
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