Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing

Monitoring antigen-specific T cells is critical for the study of immune responses and development of biomarkers and immunotherapeutics. We developed a novel multiplex assay that combines conventional immune monitoring techniques and immune receptor repertoire sequencing to enable identification of T...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0141561-e0141561
Hauptverfasser:	Klinger, Mark, Pepin, Francois, Wilkins, Jen, Asbury, Thomas, Wittkop, Tobias, Zheng, Jianbiao, Moorhead, Martin, Faham, Malek
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Biomarkers Clonal Evolution - genetics Clonal Evolution - immunology Cytomegalovirus Cytotoxicity Enzyme-linked immunosorbent assay Enzyme-Linked Immunospot Assay - methods Enzyme-Linked Immunospot Assay - standards Epitopes, T-Lymphocyte - immunology High-Throughput Nucleotide Sequencing Humans Identification Immune response Infections Influenza Lymphocytes Lymphocytes T Monitoring Multiplexing Peptides Population Receptors Receptors, Antigen, T-Cell - genetics Receptors, Immunologic - genetics Reproducibility of Results T cell receptors T cells T-Cell Antigen Receptor Specificity - genetics T-Cell Antigen Receptor Specificity - immunology Technology Technology application
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