Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

A large group of flavonoids found in fruits and vegetables have been suggested to elicit health benefits due mainly to their anti-oxidative and anti-inflammatory properties. Recent studies with immune cells have demonstrated inhibition of these inflammatory responses through down-regulation of the p...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0141509
Hauptverfasser:	Sun, Grace Y, Chen, Zihong, Jasmer, Kimberly J, Chuang, Dennis Y, Gu, Zezong, Hannink, Mark, Simonyi, Agnes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthocyanins Anti-inflammatory agents Biochemistry Carbonyl groups Carbonyls Cell culture Cytokines Enzymes Flavonoids Gene Expression Regulation - drug effects Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - biosynthesis Heme Oxygenase-1 - metabolism Homeostasis Humans Immune system Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inhibition Interdisciplinary aspects Kinases Lipopolysaccharides Lipopolysaccharides - toxicity Macrophages - drug effects Macrophages - metabolism Mice Microglia - drug effects Microglia - metabolism Microglial cells Neurosciences NF-E2-Related Factor 2 - biosynthesis NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism NF-κB protein Nitric Oxide - biosynthesis Nitric Oxide - metabolism Oxidative stress Oxygenase p38 Mitogen-Activated Protein Kinases - genetics PCB Penicillin Pharmacology Physiological aspects Polychlorinated biphenyls Polyphenols Proteins Quercetin Quercetin - administration & dosage Rodents Signal Transduction - drug effects Toxicology Vegetables
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