Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis
The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and whether it did so via the gut-liver axis. Results sh...
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| description | The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and whether it did so via the gut-liver axis. Results showed that TSG could reduce the accumulation of FFA and it did so by reducing the expression of L-FABP and FATP4. TSG regulated gut microbiota balanced and increased the protein expression of ZO-1 and occludin, which could improve the function of the intestinal mucosal barrier and reduce serum LPS content by about 25%. TSG reduced TL4 levels by 56% and NF-κB expression by 23% relative to the NAFLD model group. This suggests that prevention of NAFLD by TSG in HFD-fed rats is mediated by modulation of the gut microbiota and TLR4/NF-κB pathway, which may alleviate chronic low-grade inflammation by reducing the exogenous antigen load on the host. |
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We investigated whether 2, 3, 5, 4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and whether it did so via the gut-liver axis. Results showed that TSG could reduce the accumulation of FFA and it did so by reducing the expression of L-FABP and FATP4. TSG regulated gut microbiota balanced and increased the protein expression of ZO-1 and occludin, which could improve the function of the intestinal mucosal barrier and reduce serum LPS content by about 25%. TSG reduced TL4 levels by 56% and NF-κB expression by 23% relative to the NAFLD model group. This suggests that prevention of NAFLD by TSG in HFD-fed rats is mediated by modulation of the gut microbiota and TLR4/NF-κB pathway, which may alleviate chronic low-grade inflammation by reducing the exogenous antigen load on the host.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0140346</identifier><identifier>PMID: 26474417</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Chinese medicine ; Diet ; Diet, High-Fat - adverse effects ; Digestive system ; Digestive tract ; Drug dosages ; Fatty acid-binding protein ; Fatty acids ; Fatty liver ; Flow Cytometry ; Gastrointestinal tract ; Glucosides - pharmacology ; High fat diet ; Inflammation ; Inflammation - chemically induced ; Inflammation - microbiology ; Inflammation - prevention & control ; Intestinal microflora ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - microbiology ; Intestine ; Lipids ; Lipopolysaccharides ; Liver ; Liver - drug effects ; Liver - microbiology ; Liver cirrhosis ; Liver diseases ; Male ; Medical research ; Metabolism ; Metabolites ; Microbiota ; Microbiota (Symbiotic organisms) ; Microbiota - drug effects ; Mucosa ; NF-κB protein ; Non-alcoholic Fatty Liver Disease - chemically induced ; Non-alcoholic Fatty Liver Disease - microbiology ; Non-alcoholic Fatty Liver Disease - prevention & control ; Permeability ; Pharmacy ; Proteins ; Rats ; Rats, Sprague-Dawley ; Rodents ; Signal Transduction - drug effects ; Stilbene ; Stilbenes - pharmacology ; TLR4 protein ; Toll-like receptors ; Zonula occludens-1 protein</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0140346-e0140346</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Lin et al 2015 Lin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-20eb0075b2d5e61fed627a6584d8d021a853f3aa4484f6863426a30fc798a4813</citedby><cites>FETCH-LOGICAL-c692t-20eb0075b2d5e61fed627a6584d8d021a853f3aa4484f6863426a30fc798a4813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608713/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608713/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26474417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hribal, Marta Letizia</contributor><creatorcontrib>Lin, Pei</creatorcontrib><creatorcontrib>Lu, Jianmei</creatorcontrib><creatorcontrib>Wang, Yanfang</creatorcontrib><creatorcontrib>Gu, Wen</creatorcontrib><creatorcontrib>Yu, Jie</creatorcontrib><creatorcontrib>Zhao, Ronghua</creatorcontrib><title>Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and whether it did so via the gut-liver axis. Results showed that TSG could reduce the accumulation of FFA and it did so by reducing the expression of L-FABP and FATP4. TSG regulated gut microbiota balanced and increased the protein expression of ZO-1 and occludin, which could improve the function of the intestinal mucosal barrier and reduce serum LPS content by about 25%. TSG reduced TL4 levels by 56% and NF-κB expression by 23% relative to the NAFLD model group. This suggests that prevention of NAFLD by TSG in HFD-fed rats is mediated by modulation of the gut microbiota and TLR4/NF-κB pathway, which may alleviate chronic low-grade inflammation by reducing the exogenous antigen load on the host.</description><subject>Animals</subject><subject>Chinese medicine</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Digestive system</subject><subject>Digestive tract</subject><subject>Drug dosages</subject><subject>Fatty acid-binding protein</subject><subject>Fatty acids</subject><subject>Fatty liver</subject><subject>Flow Cytometry</subject><subject>Gastrointestinal tract</subject><subject>Glucosides - pharmacology</subject><subject>High fat diet</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - microbiology</subject><subject>Inflammation - prevention & control</subject><subject>Intestinal microflora</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Intestine</subject><subject>Lipids</subject><subject>Lipopolysaccharides</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - microbiology</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microbiota - drug effects</subject><subject>Mucosa</subject><subject>NF-κB protein</subject><subject>Non-alcoholic Fatty Liver Disease - chemically induced</subject><subject>Non-alcoholic Fatty Liver Disease - microbiology</subject><subject>Non-alcoholic Fatty Liver Disease - prevention & control</subject><subject>Permeability</subject><subject>Pharmacy</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Signal Transduction - drug effects</subject><subject>Stilbene</subject><subject>Stilbenes - pharmacology</subject><subject>TLR4 protein</subject><subject>Toll-like receptors</subject><subject>Zonula occludens-1 protein</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v2yAUhq1p09p1-wfTZmnStF04A4MB30yKujWLFDVS0-0WEYwTImJSwFHz74cbt4qnXkxcgA7Pec8HnCR5D8EIIgq_bWzrGmFGO9uoEYAYIExeJOewRHlGcoBenpzPkjfebwAoECPkdXKWE0wxhvQ8EdcitE4Yc0jnUrbO6WaVLoI2S9VYXaW3i0l6o_bKeeXTa9tkYyPt2hot0ysRwiGd6XiZ_tBeiQ7Za5FO2pAdzeN77d8mr2phvHrX7xfJ76uft5e_stl8Mr0czzJJyjxkOVBLAGixzKtCEViriuRUkILhilUgh4IVqEZCYMxwTRhBOCcCgVrSkgnMILpIPh51d8Z63nfHc0jzWC0jAERieiQqKzZ85_RWuAO3QvMHg3UrLlzQ0iheUwpLWcISL3MsKClrTAEpBSjKqpS4iFrf-2jtcqsqqZoQuzgQHd40es1Xds8xAYxCFAW-9ALO3rXKB77VXipjRKNs-5A3zouS4S7vT_-gz1fXUysRC9BNbWNc2YnyMUaQQUzKLu_RM1RcldpqGb9SraN94PB14BCZoO7DSrTe8-ni5v_Z-Z8h-_mEXSthwtpb0wZtGz8E8RGUznrvVP3UZAh4NwmP3eDdJPB-EqLbh9MHenJ6_ProL9aeAQM</recordid><startdate>20151016</startdate><enddate>20151016</enddate><creator>Lin, Pei</creator><creator>Lu, Jianmei</creator><creator>Wang, Yanfang</creator><creator>Gu, Wen</creator><creator>Yu, Jie</creator><creator>Zhao, Ronghua</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151016</creationdate><title>Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis</title><author>Lin, Pei ; Lu, Jianmei ; Wang, Yanfang ; Gu, Wen ; Yu, Jie ; Zhao, Ronghua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-20eb0075b2d5e61fed627a6584d8d021a853f3aa4484f6863426a30fc798a4813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Chinese medicine</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Digestive system</topic><topic>Digestive tract</topic><topic>Drug dosages</topic><topic>Fatty acid-binding protein</topic><topic>Fatty acids</topic><topic>Fatty liver</topic><topic>Flow Cytometry</topic><topic>Gastrointestinal tract</topic><topic>Glucosides - pharmacology</topic><topic>High fat diet</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - microbiology</topic><topic>Inflammation - prevention & control</topic><topic>Intestinal microflora</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Intestine</topic><topic>Lipids</topic><topic>Lipopolysaccharides</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - microbiology</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Microbiota - 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We investigated whether 2, 3, 5, 4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and whether it did so via the gut-liver axis. Results showed that TSG could reduce the accumulation of FFA and it did so by reducing the expression of L-FABP and FATP4. TSG regulated gut microbiota balanced and increased the protein expression of ZO-1 and occludin, which could improve the function of the intestinal mucosal barrier and reduce serum LPS content by about 25%. TSG reduced TL4 levels by 56% and NF-κB expression by 23% relative to the NAFLD model group. This suggests that prevention of NAFLD by TSG in HFD-fed rats is mediated by modulation of the gut microbiota and TLR4/NF-κB pathway, which may alleviate chronic low-grade inflammation by reducing the exogenous antigen load on the host.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26474417</pmid><doi>10.1371/journal.pone.0140346</doi><tpages>e0140346</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Chinese medicine Diet Diet, High-Fat - adverse effects Digestive system Digestive tract Drug dosages Fatty acid-binding protein Fatty acids Fatty liver Flow Cytometry Gastrointestinal tract Glucosides - pharmacology High fat diet Inflammation Inflammation - chemically induced Inflammation - microbiology Inflammation - prevention & control Intestinal microflora Intestinal Mucosa - drug effects Intestinal Mucosa - microbiology Intestine Lipids Lipopolysaccharides Liver Liver - drug effects Liver - microbiology Liver cirrhosis Liver diseases Male Medical research Metabolism Metabolites Microbiota Microbiota (Symbiotic organisms) Microbiota - drug effects Mucosa NF-κB protein Non-alcoholic Fatty Liver Disease - chemically induced Non-alcoholic Fatty Liver Disease - microbiology Non-alcoholic Fatty Liver Disease - prevention & control Permeability Pharmacy Proteins Rats Rats, Sprague-Dawley Rodents Signal Transduction - drug effects Stilbene Stilbenes - pharmacology TLR4 protein Toll-like receptors Zonula occludens-1 protein |
| title | Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T06%3A14%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Naturally%20Occurring%20Stilbenoid%20TSG%20Reverses%20Non-Alcoholic%20Fatty%20Liver%20Diseases%20via%20Gut-Liver%20Axis&rft.jtitle=PloS%20one&rft.au=Lin,%20Pei&rft.date=2015-10-16&rft.volume=10&rft.issue=10&rft.spage=e0140346&rft.epage=e0140346&rft.pages=e0140346-e0140346&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0140346&rft_dat=%3Cgale_plos_%3EA431814695%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1722648600&rft_id=info:pmid/26474417&rft_galeid=A431814695&rft_doaj_id=oai_doaj_org_article_f7719c9194b24a769f47069a059d9c45&rfr_iscdi=true |