Histone Methylation in Nickel-Smelting Industrial Workers
Nickel is an essential trace metal naturally found in the environment. It is also common in occupational settings, where it associates with various levels of both occupational and nonoccupational exposure In vitro studies have shown that nickel exposure can lead to intracellular accumulation of Ni2+...
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| creator | Ma, Li Bai, Yana Pu, Hongquan Gou, Faxiang Dai, Min Wang, Hui He, Jie Zheng, Tongzhang Cheng, Ning |
| description | Nickel is an essential trace metal naturally found in the environment. It is also common in occupational settings, where it associates with various levels of both occupational and nonoccupational exposure In vitro studies have shown that nickel exposure can lead to intracellular accumulation of Ni2+, which has been associated with global decreases in DNA methylation, increases in chromatin condensation, reductions in H3K9me2, and elevated levels of H3K4me3. Histone modifications play an important role in modulating chromatin structure and gene expression. For example, tri-methylation of histone H3k4 has been found to be associated with transcriptional activation, and tri-methylation of H3k27 has been found to be associated with transcriptional repression. Aberrant histone modifications have been found to be associated with various human diseases, including cancer. The purpose of this work was to identify biomarkers for populations with occupational nickel exposure and to examine the relationship between histone methylation and nickel exposure. This may provide a scientific indicator of early health impairment and facilitate exploration of the molecular mechanism underlying cancer pathogenesis.
One hundred and forty subjects with occupational exposure to Ni and 140 referents were recruited. H3K4 and H3K27 trimethylation levels were measured in subjects' blood cells.
H3K4me3 levels were found to be higher in nickel smelting workers (47.24±20.85) than in office workers (22.65±8.81; P = 0.000), while the opposite was found for levels of H3K27me3(nickel smelting workers, 13.88± 4.23; office workers, 20.67± 5.96; P = 0.000). H3K4me3 was positively (r = 0.267, P = 0.001) and H3K27 was negatively (r = -0.684, P = 0.000) associated with age and length of service in smelting workers.
This study indicated that occupational exposure to Ni is associated with alterations in levels of histone modification. |
| doi_str_mv | 10.1371/journal.pone.0140339 |
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One hundred and forty subjects with occupational exposure to Ni and 140 referents were recruited. H3K4 and H3K27 trimethylation levels were measured in subjects' blood cells.
H3K4me3 levels were found to be higher in nickel smelting workers (47.24±20.85) than in office workers (22.65±8.81; P = 0.000), while the opposite was found for levels of H3K27me3(nickel smelting workers, 13.88± 4.23; office workers, 20.67± 5.96; P = 0.000). H3K4me3 was positively (r = 0.267, P = 0.001) and H3K27 was negatively (r = -0.684, P = 0.000) associated with age and length of service in smelting workers.
This study indicated that occupational exposure to Ni is associated with alterations in levels of histone modification.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0140339</identifier><identifier>PMID: 26474320</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Analysis ; Bioindicators ; Biomarkers ; Biomarkers - analysis ; Blood cells ; Cancer ; Case-Control Studies ; Chromatin ; Deoxyribonucleic acid ; DNA ; DNA Methylation ; Epidemiology ; Epigenetics ; Exposure ; Factories ; Food contamination & poisoning ; Gene expression ; Gene silencing ; Health aspects ; Histone Code ; Histones ; Histones - chemistry ; Hospitals ; Humans ; Hypoxia ; Kinases ; Lung cancer ; Male ; Metallurgy ; Methylation ; Middle Aged ; Mutation ; Nickel ; Nickel (Metal) ; Nickel - adverse effects ; Occupational exposure ; Occupational Exposure - adverse effects ; Occupational health ; Occupational safety and health ; Pathogenesis ; Public health ; RNA polymerase ; Smelters ; Smelting ; Studies ; Trace metals ; Transcription activation ; Workers ; Young Adult</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0140339</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Ma et al 2015 Ma et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4ad3152c24bb240279bd9af40cdc7af27da6850ccea3fde7582b411cdc0c61713</citedby><cites>FETCH-LOGICAL-c692t-4ad3152c24bb240279bd9af40cdc7af27da6850ccea3fde7582b411cdc0c61713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608576/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608576/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26474320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Costa, Max</contributor><creatorcontrib>Ma, Li</creatorcontrib><creatorcontrib>Bai, Yana</creatorcontrib><creatorcontrib>Pu, Hongquan</creatorcontrib><creatorcontrib>Gou, Faxiang</creatorcontrib><creatorcontrib>Dai, Min</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>He, Jie</creatorcontrib><creatorcontrib>Zheng, Tongzhang</creatorcontrib><creatorcontrib>Cheng, Ning</creatorcontrib><title>Histone Methylation in Nickel-Smelting Industrial Workers</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Nickel is an essential trace metal naturally found in the environment. It is also common in occupational settings, where it associates with various levels of both occupational and nonoccupational exposure In vitro studies have shown that nickel exposure can lead to intracellular accumulation of Ni2+, which has been associated with global decreases in DNA methylation, increases in chromatin condensation, reductions in H3K9me2, and elevated levels of H3K4me3. Histone modifications play an important role in modulating chromatin structure and gene expression. For example, tri-methylation of histone H3k4 has been found to be associated with transcriptional activation, and tri-methylation of H3k27 has been found to be associated with transcriptional repression. Aberrant histone modifications have been found to be associated with various human diseases, including cancer. The purpose of this work was to identify biomarkers for populations with occupational nickel exposure and to examine the relationship between histone methylation and nickel exposure. This may provide a scientific indicator of early health impairment and facilitate exploration of the molecular mechanism underlying cancer pathogenesis.
One hundred and forty subjects with occupational exposure to Ni and 140 referents were recruited. H3K4 and H3K27 trimethylation levels were measured in subjects' blood cells.
H3K4me3 levels were found to be higher in nickel smelting workers (47.24±20.85) than in office workers (22.65±8.81; P = 0.000), while the opposite was found for levels of H3K27me3(nickel smelting workers, 13.88± 4.23; office workers, 20.67± 5.96; P = 0.000). H3K4me3 was positively (r = 0.267, P = 0.001) and H3K27 was negatively (r = -0.684, P = 0.000) associated with age and length of service in smelting workers.
This study indicated that occupational exposure to Ni is associated with alterations in levels of histone modification.</description><subject>Adult</subject><subject>Age</subject><subject>Analysis</subject><subject>Bioindicators</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Blood cells</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Chromatin</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>Epidemiology</subject><subject>Epigenetics</subject><subject>Exposure</subject><subject>Factories</subject><subject>Food contamination & poisoning</subject><subject>Gene expression</subject><subject>Gene silencing</subject><subject>Health aspects</subject><subject>Histone Code</subject><subject>Histones</subject><subject>Histones - chemistry</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Metallurgy</subject><subject>Methylation</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Nickel</subject><subject>Nickel (Metal)</subject><subject>Nickel - adverse effects</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational health</subject><subject>Occupational safety and health</subject><subject>Pathogenesis</subject><subject>Public health</subject><subject>RNA polymerase</subject><subject>Smelters</subject><subject>Smelting</subject><subject>Studies</subject><subject>Trace metals</subject><subject>Transcription activation</subject><subject>Workers</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbLv6D0QHBMGLWfM1yeSmUIrahWrB-nEZMpnMbLaZyZpkiv33Zt1p2QEFyUXCyXPenHPyZtkLCJYQM_hu40Y_SLvcukEvASQAY_4oO4Yco4IigB8fnI-ykxA2AJS4ovRpdoQoYQQjcJzxCxNiUsg_6bi-szIaN-RmyD8bdaNtcd1rG83Q5auhGUP0Rtr8h_M32odn2ZNW2qCfT_si-_bh_dfzi-Ly6uPq_OyyUJSjWBDZYFgihUhdIwIQ43XDZUuAahSTLWKNpFUJlNISt41mZYVqAmG6BYpCBvEie7XX3VoXxNR1EJCh1EVV8jIRqz3ROLkRW2966e-Ek0b8CTjfCemjUVaLRmnKOOVtQxWpS85LCLDUnHDGeAlY0jqdXhvrXid8iF7amej8ZjBr0blbQSioSkaTwOtJwLufow7xHyVPVCdTVWZoXRJTvQlKnBEMK0h237bIln-h0mp0b1T6tdak-Czh7SwhMVH_ip0cQxCr6y__z159n7NvDti1ljaug7Pjzi1hDpI9qLwLwev2YXIQiJ1t76chdrYVk21T2svDqT8k3fsU_wYAv-bQ</recordid><startdate>20151016</startdate><enddate>20151016</enddate><creator>Ma, Li</creator><creator>Bai, Yana</creator><creator>Pu, Hongquan</creator><creator>Gou, Faxiang</creator><creator>Dai, Min</creator><creator>Wang, Hui</creator><creator>He, Jie</creator><creator>Zheng, Tongzhang</creator><creator>Cheng, Ning</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151016</creationdate><title>Histone Methylation in Nickel-Smelting Industrial Workers</title><author>Ma, Li ; Bai, Yana ; Pu, Hongquan ; Gou, Faxiang ; Dai, Min ; Wang, Hui ; He, Jie ; Zheng, Tongzhang ; Cheng, Ning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4ad3152c24bb240279bd9af40cdc7af27da6850ccea3fde7582b411cdc0c61713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Analysis</topic><topic>Bioindicators</topic><topic>Biomarkers</topic><topic>Biomarkers - 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It is also common in occupational settings, where it associates with various levels of both occupational and nonoccupational exposure In vitro studies have shown that nickel exposure can lead to intracellular accumulation of Ni2+, which has been associated with global decreases in DNA methylation, increases in chromatin condensation, reductions in H3K9me2, and elevated levels of H3K4me3. Histone modifications play an important role in modulating chromatin structure and gene expression. For example, tri-methylation of histone H3k4 has been found to be associated with transcriptional activation, and tri-methylation of H3k27 has been found to be associated with transcriptional repression. Aberrant histone modifications have been found to be associated with various human diseases, including cancer. The purpose of this work was to identify biomarkers for populations with occupational nickel exposure and to examine the relationship between histone methylation and nickel exposure. This may provide a scientific indicator of early health impairment and facilitate exploration of the molecular mechanism underlying cancer pathogenesis.
One hundred and forty subjects with occupational exposure to Ni and 140 referents were recruited. H3K4 and H3K27 trimethylation levels were measured in subjects' blood cells.
H3K4me3 levels were found to be higher in nickel smelting workers (47.24±20.85) than in office workers (22.65±8.81; P = 0.000), while the opposite was found for levels of H3K27me3(nickel smelting workers, 13.88± 4.23; office workers, 20.67± 5.96; P = 0.000). H3K4me3 was positively (r = 0.267, P = 0.001) and H3K27 was negatively (r = -0.684, P = 0.000) associated with age and length of service in smelting workers.
This study indicated that occupational exposure to Ni is associated with alterations in levels of histone modification.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26474320</pmid><doi>10.1371/journal.pone.0140339</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-10, Vol.10 (10), p.e0140339 |
| issn | 1932-6203 1932-6203 |
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| recordid | cdi_plos_journals_1722648595 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Free E-Journal (出版社公開部分のみ）; PLoS_OA刊; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Analysis Bioindicators Biomarkers Biomarkers - analysis Blood cells Cancer Case-Control Studies Chromatin Deoxyribonucleic acid DNA DNA Methylation Epidemiology Epigenetics Exposure Factories Food contamination & poisoning Gene expression Gene silencing Health aspects Histone Code Histones Histones - chemistry Hospitals Humans Hypoxia Kinases Lung cancer Male Metallurgy Methylation Middle Aged Mutation Nickel Nickel (Metal) Nickel - adverse effects Occupational exposure Occupational Exposure - adverse effects Occupational health Occupational safety and health Pathogenesis Public health RNA polymerase Smelters Smelting Studies Trace metals Transcription activation Workers Young Adult |
| title | Histone Methylation in Nickel-Smelting Industrial Workers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T06%3A52%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histone%20Methylation%20in%20Nickel-Smelting%20Industrial%20Workers&rft.jtitle=PloS%20one&rft.au=Ma,%20Li&rft.date=2015-10-16&rft.volume=10&rft.issue=10&rft.spage=e0140339&rft.pages=e0140339-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0140339&rft_dat=%3Cgale_plos_%3EA431814620%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1722648595&rft_id=info:pmid/26474320&rft_galeid=A431814620&rft_doaj_id=oai_doaj_org_article_dce67969fd6c4b5995103ae949779507&rfr_iscdi=true |