Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy

The molecular mechanisms underlying epileptogenesis have been widely investigated by differential gene expression approach, especially RT-qPCR methodology. However, controversial findings highlight the occurrence of unpredictable sources of variance in the experimental designs. Here, we investigated...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0141121-e0141121
Hauptverfasser:	Santos, Evelin Antonieli da Silva, Marques, Thalita Ewellyn Batista Sales, Matos, Heloísa de Carvalho, Leite, João Pereira, Garcia-Cairasco, Norberto, Paçó-Larson, Maria Luisa, Gitaí, Daniel Leite Góes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BMAL1 protein Care and treatment Circadian Rhythm - genetics Circadian rhythms Cryptochromes Darkness Diurnal Dosage and administration Epilepsy Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - genetics Epilepsy, Temporal Lobe - physiopathology Gene expression Genes Genetic engineering Hippocampus Hippocampus - drug effects Hippocampus - metabolism Male Molecular biology Molecular modelling Neurogenesis Neurosciences Oscillations Pathogenesis Period 1 protein Period 3 protein Pilocarpine Pilocarpine - pharmacology Rats Rats, Wistar Rhythm Rhythms Risk factors RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Seizures (Medicine) Statistical analysis Statistical tests Temporal lobe Temporal lobe epilepsy Transcription Transcriptome - drug effects Transcriptome - physiology
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