A Single-Dose Intra-Articular Morphine plus Bupivacaine versus Morphine Alone following Knee Arthroscopy: A Systematic Review and Meta-Analysis
The purpose of this study was to compare the efficacy and safety of a single-dose intra-articular morphine plus bupivacaine versus morphine alone in patients undergoing arthroscopic knee surgery. Randomized controlled trials comparing a combination of morphine and bupivacaine with morphine alone inj...
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| description | The purpose of this study was to compare the efficacy and safety of a single-dose intra-articular morphine plus bupivacaine versus morphine alone in patients undergoing arthroscopic knee surgery.
Randomized controlled trials comparing a combination of morphine and bupivacaine with morphine alone injected intra-articularly in the management of pain after knee arthrocopic surgery were retrieved (up to August 10, 2014) from MEDLINE, the Cochrane Library and Embase databases. The weighted mean difference (WMD), relative risk (RR) and their corresponding 95% confidence intervals (CIs) were calculated using RevMan statistical software.
Thirteen randomized controlled trials were included. Statistically significant differences were observed with regard to the VAS values during the immediate period (0-2h) (WMD -1.16; 95% CI -2.01 to -0.31; p = 0.007) and the time to first request for rescue analgesia (WMD = 2.05; 95% CI 0.19 to 3.92; p = 0.03). However, there was no significant difference in the VAS pain score during the early period (2-6h) (WMD -0.36; 95% CI -1.13 to 0.41; p = 0.35), the late period (6-48h) (WMD 0.11; 95% CI -0.40 to 0.63; p = 0.67), and the number of patients requiring supplementary analgesia (RR = 0.78; 95% CI 0.57 to 1.05; p = 0.10). In addition, systematic review showed that intra-articular morphine plus bupivacaine would not increase the incidence of adverse effects compared with morphine alone.
The present study suggested that the administration of single-dose intra-articular morphine plus bupivacaine provided better pain relief during the immediate period (0-2h), and lengthened the time interval before the first request for analgesic rescue without increasing the short-term side effects when compared with morphine alone.
Level I, meta-analysis of Level I studies. |
| doi_str_mv | 10.1371/journal.pone.0140512 |
| format | Article |
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Randomized controlled trials comparing a combination of morphine and bupivacaine with morphine alone injected intra-articularly in the management of pain after knee arthrocopic surgery were retrieved (up to August 10, 2014) from MEDLINE, the Cochrane Library and Embase databases. The weighted mean difference (WMD), relative risk (RR) and their corresponding 95% confidence intervals (CIs) were calculated using RevMan statistical software.
Thirteen randomized controlled trials were included. Statistically significant differences were observed with regard to the VAS values during the immediate period (0-2h) (WMD -1.16; 95% CI -2.01 to -0.31; p = 0.007) and the time to first request for rescue analgesia (WMD = 2.05; 95% CI 0.19 to 3.92; p = 0.03). However, there was no significant difference in the VAS pain score during the early period (2-6h) (WMD -0.36; 95% CI -1.13 to 0.41; p = 0.35), the late period (6-48h) (WMD 0.11; 95% CI -0.40 to 0.63; p = 0.67), and the number of patients requiring supplementary analgesia (RR = 0.78; 95% CI 0.57 to 1.05; p = 0.10). In addition, systematic review showed that intra-articular morphine plus bupivacaine would not increase the incidence of adverse effects compared with morphine alone.
The present study suggested that the administration of single-dose intra-articular morphine plus bupivacaine provided better pain relief during the immediate period (0-2h), and lengthened the time interval before the first request for analgesic rescue without increasing the short-term side effects when compared with morphine alone.
Level I, meta-analysis of Level I studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0140512</identifier><identifier>PMID: 26474401</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analgesia ; Analgesics ; Analysis ; Anesthesia ; Arthroscopy ; Arthroscopy - adverse effects ; Bupivacaine ; Bupivacaine - administration & dosage ; Bupivacaine - adverse effects ; Bupivacaine - pharmacology ; Clinical trials ; Confidence intervals ; Dosage and administration ; English literature ; Epidemiology ; Hospitals ; Humans ; Knee ; Knee - surgery ; Knee Joint ; Meta-analysis ; Morphine ; Morphine - administration & dosage ; Morphine - adverse effects ; Morphine - pharmacology ; Pain ; Pain Management - adverse effects ; Pain Management - methods ; Pain perception ; Patients ; Public health ; Randomization ; Side effects ; Statistical analysis ; Studies ; Surgery ; Systematic review ; Weapons of mass destruction</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0140512-e0140512</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Xie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Xie et al 2015 Xie et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-cc99d50c97103dcadbd502e3af38c6a9e8473fa807d271356128c1796946cc3d3</citedby><cites>FETCH-LOGICAL-c692t-cc99d50c97103dcadbd502e3af38c6a9e8473fa807d271356128c1796946cc3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608597/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608597/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26474401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Dong-Xing</creatorcontrib><creatorcontrib>Zeng, Chao</creatorcontrib><creatorcontrib>Wang, Yi-Lun</creatorcontrib><creatorcontrib>Li, Yu-Sheng</creatorcontrib><creatorcontrib>Wei, Jie</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Yang, Tuo</creatorcontrib><creatorcontrib>Yang, Tu-Bao</creatorcontrib><creatorcontrib>Lei, Guang-Hua</creatorcontrib><title>A Single-Dose Intra-Articular Morphine plus Bupivacaine versus Morphine Alone following Knee Arthroscopy: A Systematic Review and Meta-Analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The purpose of this study was to compare the efficacy and safety of a single-dose intra-articular morphine plus bupivacaine versus morphine alone in patients undergoing arthroscopic knee surgery.
Randomized controlled trials comparing a combination of morphine and bupivacaine with morphine alone injected intra-articularly in the management of pain after knee arthrocopic surgery were retrieved (up to August 10, 2014) from MEDLINE, the Cochrane Library and Embase databases. The weighted mean difference (WMD), relative risk (RR) and their corresponding 95% confidence intervals (CIs) were calculated using RevMan statistical software.
Thirteen randomized controlled trials were included. Statistically significant differences were observed with regard to the VAS values during the immediate period (0-2h) (WMD -1.16; 95% CI -2.01 to -0.31; p = 0.007) and the time to first request for rescue analgesia (WMD = 2.05; 95% CI 0.19 to 3.92; p = 0.03). However, there was no significant difference in the VAS pain score during the early period (2-6h) (WMD -0.36; 95% CI -1.13 to 0.41; p = 0.35), the late period (6-48h) (WMD 0.11; 95% CI -0.40 to 0.63; p = 0.67), and the number of patients requiring supplementary analgesia (RR = 0.78; 95% CI 0.57 to 1.05; p = 0.10). In addition, systematic review showed that intra-articular morphine plus bupivacaine would not increase the incidence of adverse effects compared with morphine alone.
The present study suggested that the administration of single-dose intra-articular morphine plus bupivacaine provided better pain relief during the immediate period (0-2h), and lengthened the time interval before the first request for analgesic rescue without increasing the short-term side effects when compared with morphine alone.
Level I, meta-analysis of Level I studies.</description><subject>Analgesia</subject><subject>Analgesics</subject><subject>Analysis</subject><subject>Anesthesia</subject><subject>Arthroscopy</subject><subject>Arthroscopy - adverse effects</subject><subject>Bupivacaine</subject><subject>Bupivacaine - administration & dosage</subject><subject>Bupivacaine - adverse effects</subject><subject>Bupivacaine - pharmacology</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Dosage and administration</subject><subject>English literature</subject><subject>Epidemiology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Knee</subject><subject>Knee - surgery</subject><subject>Knee Joint</subject><subject>Meta-analysis</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - adverse effects</subject><subject>Morphine - pharmacology</subject><subject>Pain</subject><subject>Pain Management - adverse effects</subject><subject>Pain Management - methods</subject><subject>Pain perception</subject><subject>Patients</subject><subject>Public health</subject><subject>Randomization</subject><subject>Side effects</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Weapons of mass destruction</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99u0zAUxiMEYmPwBggiISG4SLFjx4l3gVTGv4pNkzbg1nKdk9aVGwc76ehT8Mo4a1Y1aBcoF0lOfuc7Pt_JiaLnGE0wyfG7le1cLc2ksTVMEKYow-mD6BhzkiYsReThwfNR9MT7FUIZKRh7HB2ljOaUInwc_ZnG17peGEg-Wg_xrG6dTKau1aoz0sUX1jVLXUPcmM7HH7pGb6SSfWADzofQHpiacI64ssbYmyAYf6shBF27dNYr22xP41Bp61tYyyAeX8FGw00s6zK-gDaUDK1svfZPo0eVNB6eDfeT6MfnT9_Pvibnl19mZ9PzRDGetolSnJcZUjzHiJRKlvPwlgKRFSkUkxwKmpNKFigv0xyTjOG0UDjnjFOmFCnJSfRyp9sY68XgpRc4T4M3Bc2yQMx2RGnlSjROr6XbCiu1uA1YtxCy98mAUBjn8yxHpKjmlGEsEU-By4pX87Ikqtd6P1Tr5msoFfQ2m5Ho-Eutl2JhN4IyVGQ8DwJvBgFnf3XgW7HWXoExsgbb3Z6bplkYNwnoq3_Q-7sbqIUMDei6sqGu6kXFlBJcYMoKHKjJPVS4SlhrFQZe6RAfJbwdJQSmhd_tQnbei9n11f-zlz_H7OsDdgnStEtvTddqW_sxSHegCv-dd1DtTcZI9Htz54bo90YMexPSXhwOaJ90tyjkL8yiE74</recordid><startdate>20151016</startdate><enddate>20151016</enddate><creator>Xie, Dong-Xing</creator><creator>Zeng, Chao</creator><creator>Wang, Yi-Lun</creator><creator>Li, Yu-Sheng</creator><creator>Wei, Jie</creator><creator>Li, Hui</creator><creator>Yang, Tuo</creator><creator>Yang, Tu-Bao</creator><creator>Lei, Guang-Hua</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151016</creationdate><title>A Single-Dose Intra-Articular Morphine plus Bupivacaine versus Morphine Alone following Knee Arthroscopy: A Systematic Review and Meta-Analysis</title><author>Xie, Dong-Xing ; Zeng, Chao ; Wang, Yi-Lun ; Li, Yu-Sheng ; Wei, Jie ; Li, Hui ; Yang, Tuo ; Yang, Tu-Bao ; Lei, Guang-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-cc99d50c97103dcadbd502e3af38c6a9e8473fa807d271356128c1796946cc3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analgesia</topic><topic>Analgesics</topic><topic>Analysis</topic><topic>Anesthesia</topic><topic>Arthroscopy</topic><topic>Arthroscopy - adverse effects</topic><topic>Bupivacaine</topic><topic>Bupivacaine - administration & dosage</topic><topic>Bupivacaine - adverse effects</topic><topic>Bupivacaine - pharmacology</topic><topic>Clinical trials</topic><topic>Confidence intervals</topic><topic>Dosage and administration</topic><topic>English literature</topic><topic>Epidemiology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Knee</topic><topic>Knee - surgery</topic><topic>Knee Joint</topic><topic>Meta-analysis</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - adverse effects</topic><topic>Morphine - pharmacology</topic><topic>Pain</topic><topic>Pain Management - adverse effects</topic><topic>Pain Management - methods</topic><topic>Pain perception</topic><topic>Patients</topic><topic>Public health</topic><topic>Randomization</topic><topic>Side effects</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Surgery</topic><topic>Systematic review</topic><topic>Weapons of mass destruction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Dong-Xing</creatorcontrib><creatorcontrib>Zeng, Chao</creatorcontrib><creatorcontrib>Wang, Yi-Lun</creatorcontrib><creatorcontrib>Li, Yu-Sheng</creatorcontrib><creatorcontrib>Wei, Jie</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Yang, Tuo</creatorcontrib><creatorcontrib>Yang, Tu-Bao</creatorcontrib><creatorcontrib>Lei, Guang-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Dong-Xing</au><au>Zeng, Chao</au><au>Wang, Yi-Lun</au><au>Li, Yu-Sheng</au><au>Wei, Jie</au><au>Li, Hui</au><au>Yang, Tuo</au><au>Yang, Tu-Bao</au><au>Lei, Guang-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Single-Dose Intra-Articular Morphine plus Bupivacaine versus Morphine Alone following Knee Arthroscopy: A Systematic Review and Meta-Analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-10-16</date><risdate>2015</risdate><volume>10</volume><issue>10</issue><spage>e0140512</spage><epage>e0140512</epage><pages>e0140512-e0140512</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The purpose of this study was to compare the efficacy and safety of a single-dose intra-articular morphine plus bupivacaine versus morphine alone in patients undergoing arthroscopic knee surgery.
Randomized controlled trials comparing a combination of morphine and bupivacaine with morphine alone injected intra-articularly in the management of pain after knee arthrocopic surgery were retrieved (up to August 10, 2014) from MEDLINE, the Cochrane Library and Embase databases. The weighted mean difference (WMD), relative risk (RR) and their corresponding 95% confidence intervals (CIs) were calculated using RevMan statistical software.
Thirteen randomized controlled trials were included. Statistically significant differences were observed with regard to the VAS values during the immediate period (0-2h) (WMD -1.16; 95% CI -2.01 to -0.31; p = 0.007) and the time to first request for rescue analgesia (WMD = 2.05; 95% CI 0.19 to 3.92; p = 0.03). However, there was no significant difference in the VAS pain score during the early period (2-6h) (WMD -0.36; 95% CI -1.13 to 0.41; p = 0.35), the late period (6-48h) (WMD 0.11; 95% CI -0.40 to 0.63; p = 0.67), and the number of patients requiring supplementary analgesia (RR = 0.78; 95% CI 0.57 to 1.05; p = 0.10). In addition, systematic review showed that intra-articular morphine plus bupivacaine would not increase the incidence of adverse effects compared with morphine alone.
The present study suggested that the administration of single-dose intra-articular morphine plus bupivacaine provided better pain relief during the immediate period (0-2h), and lengthened the time interval before the first request for analgesic rescue without increasing the short-term side effects when compared with morphine alone.
Level I, meta-analysis of Level I studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26474401</pmid><doi>10.1371/journal.pone.0140512</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1722648455 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analgesia Analgesics Analysis Anesthesia Arthroscopy Arthroscopy - adverse effects Bupivacaine Bupivacaine - administration & dosage Bupivacaine - adverse effects Bupivacaine - pharmacology Clinical trials Confidence intervals Dosage and administration English literature Epidemiology Hospitals Humans Knee Knee - surgery Knee Joint Meta-analysis Morphine Morphine - administration & dosage Morphine - adverse effects Morphine - pharmacology Pain Pain Management - adverse effects Pain Management - methods Pain perception Patients Public health Randomization Side effects Statistical analysis Studies Surgery Systematic review Weapons of mass destruction |
| title | A Single-Dose Intra-Articular Morphine plus Bupivacaine versus Morphine Alone following Knee Arthroscopy: A Systematic Review and Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T23%3A24%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Single-Dose%20Intra-Articular%20Morphine%20plus%20Bupivacaine%20versus%20Morphine%20Alone%20following%20Knee%20Arthroscopy:%20A%20Systematic%20Review%20and%20Meta-Analysis&rft.jtitle=PloS%20one&rft.au=Xie,%20Dong-Xing&rft.date=2015-10-16&rft.volume=10&rft.issue=10&rft.spage=e0140512&rft.epage=e0140512&rft.pages=e0140512-e0140512&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0140512&rft_dat=%3Cgale_plos_%3EA431814681%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1722648455&rft_id=info:pmid/26474401&rft_galeid=A431814681&rft_doaj_id=oai_doaj_org_article_c117b57038fb4611a092e9af9fbdd3c5&rfr_iscdi=true |