Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission

Pregnant HIV-infected women were screened for the development of HIV-1 drug resistance after implementation of a triple-antiretroviral transmission prophylaxis as recommended by the WHO in 2006. The study offered the opportunity to compare amplicon-based 454 ultra-deep sequencing (UDS) and allele-sp...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140809
Hauptverfasser:	Hauser, Andrea, Kuecherer, Claudia, Kunz, Andrea, Dabrowski, Piotr Wojtek, Radonić, Aleksandar, Nitsche, Andreas, Theuring, Stefanie, Bannert, Norbert, Sewangi, Julius, Mbezi, Paulina, Dugange, Festo, Harms, Gundel, Meixenberger, Karolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Comparative analysis Development and progression Disease transmission DNA sequencing Drug resistance Drug Resistance, Viral - genetics Drug therapy Female Genetic aspects GLP-1 receptor agonists High-Throughput Nucleotide Sequencing - methods HIV HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - virology HIV-1 - genetics Human immunodeficiency virus Humans Infectious Disease Transmission, Vertical - prevention & control Mutation Physiological aspects Post-Exposure Prophylaxis - methods Pregnancy Pregnancy Complications, Infectious - classification Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - virology Prognosis Prophylaxis Real time Real-Time Polymerase Chain Reaction - methods RNA-directed DNA polymerase Sampling methods Tanzania Treatment Failure Viruses Women Zidovudine
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