Suppression of Locomotor Activity in Female C57Bl/6J Mice Treated with Interleukin-1β: Investigating a Method for the Study of Fatigue in Laboratory Animals

Fatigue is a disabling symptom in patients with multiple sclerosis and Parkinson's Disease, and is also common in patients with traumatic brain injury, cancer, and inflammatory disorders. Little is known about the neurobiology of fatigue, in part due to the lack of an approach to induce fatigue...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140678
Hauptverfasser:	Bonsall, David R, Kim, Hyunji, Tocci, Catherine, Ndiaye, Awa, Petronzio, Abbey, McKay-Corkum, Grace, Molyneux, Penny C, Scammell, Thomas E, Harrington, Mary E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Animals, Laboratory Behavior Behavior, Animal - drug effects Brain Buprenorphine Cancer Cancer therapies Chemotherapy Chronic fatigue syndrome Cytokines Disease Models, Animal Dopamine Down-Regulation - drug effects Fatigue Fatigue - chemically induced Fatigue - pathology Female Females Gene expression Head injuries Hedonic response Hyperthermia Hypotheses Inflammation Inflammatory diseases Infusions, Intraventricular Interleukin 1 Interleukin-1beta - administration & dosage Interleukin-1beta - pharmacology Laboratory animals Laboratory tests Locomotor activity Methylphenidate Mice Mice, Inbred C57BL Middle age Modafinil Motor Activity - drug effects Multiple sclerosis Nervous system Neurosciences Orexins Ovarian cancer Pain Patients Physical Conditioning, Animal Psychopharmacology Rodents Social research Studies Sucrose Sugar Temperature preferences Temperature probes Traumatic brain injury Womens health
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