Gedunin and Azadiradione: Human Pancreatic Alpha-Amylase Inhibiting Limonoids from Neem (Azadirachta indica) as Anti-Diabetic Agents

Human pancreatic α-amylase (HPA) inhibitors offer an effective strategy to lower postprandial hyperglycemia via control of starch breakdown. Limonoids from Azadirachta indica known for their therapeutic potential were screened for pancreatic α-amylase inhibition, a known anti-diabetic target. Studie...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140113
Hauptverfasser:	Ponnusamy, Sudha, Haldar, Saikat, Mulani, Fayaj, Zinjarde, Smita, Thulasiram, Hirekodathakallu, RaviKumar, Ameeta
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amylases - antagonists & inhibitors alpha-Amylases - chemistry Amino acids Amylases Animals Antidiabetics Azadirachta - chemistry Azadirachta indica Binding Biocompatibility Bioinformatics Biological activity Biology Biotechnology Cell Line Cytotoxicity Diabetes Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - enzymology Drug development Drug therapy Enzymes Fluorescence Glycoside Hydrolase Inhibitors - pharmacology Health aspects Herbal medicine Humans Hyperglycemia Hypoglycemia Hypoglycemic agents Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Inhibition Inhibitors Kinetics Laboratories Limonins - analysis Limonins - chemistry Limonins - pharmacology Limonoids Mode of action Models, Molecular Molecular docking Molecular Docking Simulation Neem Organic chemistry Pancreas Phaseolus vulgaris Plant Extracts - chemistry Plant Extracts - pharmacology Rats Starch Studies Substrates Toxicity Tryptophan Tyrosine α-Amylase
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