Clinical Significance of Preoperative Thrombin Time in Patients with Esophageal Squamous Cell Carcinoma following Surgical Resection
Noninvasive tools for the prognosis of ESCC are urgently needed. To this end, serum coagulation tests have been researched in some cancers, but the prognostic value of the TT in ESCC has not been described. The levels of pre-treatment serum coagulation markers (including the PT, APTT, PTA, INR, fibr...
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| creator | Li, Xiao-Hui Wang, Xue-Ping Gu, Wen-Shen Lin, Jian-Hua Huang, Hao Kang, Ting Zhang, Lin Chen, Hao Zheng, Xin |
| description | Noninvasive tools for the prognosis of ESCC are urgently needed. To this end, serum coagulation tests have been researched in some cancers, but the prognostic value of the TT in ESCC has not been described.
The levels of pre-treatment serum coagulation markers (including the PT, APTT, PTA, INR, fibrinogen level, TT and PLT) were retrospectively analyzed in 204 patients with ESCC who underwent surgical resection at our department and in 200 healthy controls, and the two groups were compared. The prognostic significance of the coagulation tests was then determined with univariate and multivariate cox hazard analyses in patients with ESCC.
Compared with those in normal controls, the PT, APTT, and fibrinogen levels were significantly increased, whereas the TT values significantly decreased in the 204 ESCC patients. The TT directly correlated with the 5-year survival rate, not only in the entire ESCC cohort (p = 0.023) but also in the subgroups stratified according to the T and N classifications and metastasis. Conversely, the other tests were not independent prognostic factors for ESCC. Of the clotting markers, the TT inversely correlated with the fibrinogen level (p = 0.005).
The 5-year survival was shorter in ESCC patients exhibiting decreased pre-treatment TT values. Thus, the serum TT may be a clinical prognostic factor for ESCC patients. |
| doi_str_mv | 10.1371/journal.pone.0140323 |
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The levels of pre-treatment serum coagulation markers (including the PT, APTT, PTA, INR, fibrinogen level, TT and PLT) were retrospectively analyzed in 204 patients with ESCC who underwent surgical resection at our department and in 200 healthy controls, and the two groups were compared. The prognostic significance of the coagulation tests was then determined with univariate and multivariate cox hazard analyses in patients with ESCC.
Compared with those in normal controls, the PT, APTT, and fibrinogen levels were significantly increased, whereas the TT values significantly decreased in the 204 ESCC patients. The TT directly correlated with the 5-year survival rate, not only in the entire ESCC cohort (p = 0.023) but also in the subgroups stratified according to the T and N classifications and metastasis. Conversely, the other tests were not independent prognostic factors for ESCC. Of the clotting markers, the TT inversely correlated with the fibrinogen level (p = 0.005).
The 5-year survival was shorter in ESCC patients exhibiting decreased pre-treatment TT values. Thus, the serum TT may be a clinical prognostic factor for ESCC patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0140323</identifier><identifier>PMID: 26469700</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - blood ; Blood Coagulation Tests - methods ; Breast cancer ; Cancer therapies ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Care and treatment ; Chemotherapy ; Clinical significance ; Clotting ; Coagulation ; Collaboration ; Colorectal cancer ; Comparative analysis ; Embolisms ; Esophageal cancer ; Esophageal Neoplasms - blood ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophageal Squamous Cell Carcinoma ; Esophagus ; Female ; Fibrinogen ; Gallbladder ; Humans ; Laboratories ; Male ; Markers ; Medical prognosis ; Medicine ; Metastases ; Metastasis ; Middle Aged ; Oncology ; Pancreatic cancer ; Patients ; Physiological aspects ; Pretreatment ; Prognosis ; Squamous cell carcinoma ; Studies ; Subgroups ; Surgery ; Surgical instruments ; Survival ; Survival Analysis ; Thrombin ; Thrombin Time ; Thromboembolism ; Thrombosis ; Tumors</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0140323-e0140323</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Li et al 2015 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ca21158cdbca67b8f6a75de609133c2cb17e060c09ef532a2ab62bf2c092bf73</citedby><cites>FETCH-LOGICAL-c692t-ca21158cdbca67b8f6a75de609133c2cb17e060c09ef532a2ab62bf2c092bf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607453/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607453/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26469700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>St-Pierre, Yves</contributor><creatorcontrib>Li, Xiao-Hui</creatorcontrib><creatorcontrib>Wang, Xue-Ping</creatorcontrib><creatorcontrib>Gu, Wen-Shen</creatorcontrib><creatorcontrib>Lin, Jian-Hua</creatorcontrib><creatorcontrib>Huang, Hao</creatorcontrib><creatorcontrib>Kang, Ting</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Chen, Hao</creatorcontrib><creatorcontrib>Zheng, Xin</creatorcontrib><title>Clinical Significance of Preoperative Thrombin Time in Patients with Esophageal Squamous Cell Carcinoma following Surgical Resection</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Noninvasive tools for the prognosis of ESCC are urgently needed. To this end, serum coagulation tests have been researched in some cancers, but the prognostic value of the TT in ESCC has not been described.
The levels of pre-treatment serum coagulation markers (including the PT, APTT, PTA, INR, fibrinogen level, TT and PLT) were retrospectively analyzed in 204 patients with ESCC who underwent surgical resection at our department and in 200 healthy controls, and the two groups were compared. The prognostic significance of the coagulation tests was then determined with univariate and multivariate cox hazard analyses in patients with ESCC.
Compared with those in normal controls, the PT, APTT, and fibrinogen levels were significantly increased, whereas the TT values significantly decreased in the 204 ESCC patients. The TT directly correlated with the 5-year survival rate, not only in the entire ESCC cohort (p = 0.023) but also in the subgroups stratified according to the T and N classifications and metastasis. Conversely, the other tests were not independent prognostic factors for ESCC. Of the clotting markers, the TT inversely correlated with the fibrinogen level (p = 0.005).
The 5-year survival was shorter in ESCC patients exhibiting decreased pre-treatment TT values. Thus, the serum TT may be a clinical prognostic factor for ESCC patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - blood</subject><subject>Blood Coagulation Tests - methods</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical significance</subject><subject>Clotting</subject><subject>Coagulation</subject><subject>Collaboration</subject><subject>Colorectal cancer</subject><subject>Comparative analysis</subject><subject>Embolisms</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - blood</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophageal Squamous Cell Carcinoma</subject><subject>Esophagus</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Gallbladder</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Markers</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Pretreatment</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Surgery</subject><subject>Surgical instruments</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Thrombin</subject><subject>Thrombin Time</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkJw0eKPxGlukKZqQKVJm9aKW-vEdVJXjt3ZyQb3_HCcNpsatAuUi2MdP-c99hufJHlL8JSwnHzZus5bMNOds2qKSYoZZc-SU1IwOuEUs-dH65PkVQhbjDM24_xlckJ5yosc49Pkz9xoqyUYtNS11VVcWqmQq9C1V26nPLT6TqHVxrum1BatdKNQjNcxr2wb0L1uN-giuN0GatXL3HbQuC6guTIGzcFLbV0DqHLGuHtta7TsfL3veKOCkq129nXyogIT1JshniWrbxer-Y_J5dX3xfz8ciJ5QduJBEpINpPrUgLPy1nFIc_WiuOCMCapLEmuMMcSF6rKGAUKJadlRWMihpydJe8Psjvjghj8C4LklKY5oxhHYnEg1g62Yud1A_63cKDFPuF8LcC3WholZmoWDwNlqVKZprQEUhJMyyLFOWRpBlHr69CtKxu1ltEtD2YkOt6xeiNqdydSjvM0Y1Hg0yDg3W2nQisaHWR0FayKBu_PXdCiKHhEP_yDPn27gaohXkDbysW-shcV5ykjPM8J6bWmT1DxW6tGy_jYKh3zo4LPo4LItOpXW0MXglgsb_6fvfo5Zj8esZv4uNpNcKbrX0wYg-kBlN6F4FX1aDLBop-VBzdEPytimJVY9u74Bz0WPQwH-wtRZBB0</recordid><startdate>20151015</startdate><enddate>20151015</enddate><creator>Li, 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Significance of Preoperative Thrombin Time in Patients with Esophageal Squamous Cell Carcinoma following Surgical Resection</title><author>Li, Xiao-Hui ; Wang, Xue-Ping ; Gu, Wen-Shen ; Lin, Jian-Hua ; Huang, Hao ; Kang, Ting ; Zhang, Lin ; Chen, Hao ; Zheng, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ca21158cdbca67b8f6a75de609133c2cb17e060c09ef532a2ab62bf2c092bf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - blood</topic><topic>Blood Coagulation Tests - methods</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Clinical significance</topic><topic>Clotting</topic><topic>Coagulation</topic><topic>Collaboration</topic><topic>Colorectal cancer</topic><topic>Comparative analysis</topic><topic>Embolisms</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - blood</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophageal Squamous Cell Carcinoma</topic><topic>Esophagus</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Gallbladder</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Male</topic><topic>Markers</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Pancreatic cancer</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Pretreatment</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Surgery</topic><topic>Surgical instruments</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Thrombin</topic><topic>Thrombin Time</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiao-Hui</creatorcontrib><creatorcontrib>Wang, Xue-Ping</creatorcontrib><creatorcontrib>Gu, Wen-Shen</creatorcontrib><creatorcontrib>Lin, Jian-Hua</creatorcontrib><creatorcontrib>Huang, Hao</creatorcontrib><creatorcontrib>Kang, Ting</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Chen, Hao</creatorcontrib><creatorcontrib>Zheng, Xin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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Significance of Preoperative Thrombin Time in Patients with Esophageal Squamous Cell Carcinoma following Surgical Resection</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-10-15</date><risdate>2015</risdate><volume>10</volume><issue>10</issue><spage>e0140323</spage><epage>e0140323</epage><pages>e0140323-e0140323</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Noninvasive tools for the prognosis of ESCC are urgently needed. To this end, serum coagulation tests have been researched in some cancers, but the prognostic value of the TT in ESCC has not been described.
The levels of pre-treatment serum coagulation markers (including the PT, APTT, PTA, INR, fibrinogen level, TT and PLT) were retrospectively analyzed in 204 patients with ESCC who underwent surgical resection at our department and in 200 healthy controls, and the two groups were compared. The prognostic significance of the coagulation tests was then determined with univariate and multivariate cox hazard analyses in patients with ESCC.
Compared with those in normal controls, the PT, APTT, and fibrinogen levels were significantly increased, whereas the TT values significantly decreased in the 204 ESCC patients. The TT directly correlated with the 5-year survival rate, not only in the entire ESCC cohort (p = 0.023) but also in the subgroups stratified according to the T and N classifications and metastasis. Conversely, the other tests were not independent prognostic factors for ESCC. Of the clotting markers, the TT inversely correlated with the fibrinogen level (p = 0.005).
The 5-year survival was shorter in ESCC patients exhibiting decreased pre-treatment TT values. Thus, the serum TT may be a clinical prognostic factor for ESCC patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26469700</pmid><doi>10.1371/journal.pone.0140323</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-10, Vol.10 (10), p.e0140323-e0140323 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Biomarkers, Tumor - blood Blood Coagulation Tests - methods Breast cancer Cancer therapies Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Care and treatment Chemotherapy Clinical significance Clotting Coagulation Collaboration Colorectal cancer Comparative analysis Embolisms Esophageal cancer Esophageal Neoplasms - blood Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophageal Squamous Cell Carcinoma Esophagus Female Fibrinogen Gallbladder Humans Laboratories Male Markers Medical prognosis Medicine Metastases Metastasis Middle Aged Oncology Pancreatic cancer Patients Physiological aspects Pretreatment Prognosis Squamous cell carcinoma Studies Subgroups Surgery Surgical instruments Survival Survival Analysis Thrombin Thrombin Time Thromboembolism Thrombosis Tumors |
| title | Clinical Significance of Preoperative Thrombin Time in Patients with Esophageal Squamous Cell Carcinoma following Surgical Resection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T09%3A07%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20Significance%20of%20Preoperative%20Thrombin%20Time%20in%20Patients%20with%20Esophageal%20Squamous%20Cell%20Carcinoma%20following%20Surgical%20Resection&rft.jtitle=PloS%20one&rft.au=Li,%20Xiao-Hui&rft.date=2015-10-15&rft.volume=10&rft.issue=10&rft.spage=e0140323&rft.epage=e0140323&rft.pages=e0140323-e0140323&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0140323&rft_dat=%3Cgale_plos_%3EA431677116%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1722473200&rft_id=info:pmid/26469700&rft_galeid=A431677116&rft_doaj_id=oai_doaj_org_article_8e8115abbe4c442ba1b102b9407a545a&rfr_iscdi=true |