microRNA-17 Is the Most Up-Regulated Member of the miR-17-92 Cluster during Early Colon Cancer Evolution

Deregulated microRNAs play a role in the development and progression of colon cancer, but little is known about their tissue and cell distribution in the continuum of normal mucosa through the premalignant adenoma to invasive adenocarcinoma. The aim of this study was to examine the expression patter...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140503-e0140503
Hauptverfasser:	Knudsen, Kirsten Nguyen, Nielsen, Boye Schnack, Lindebjerg, Jan, Hansen, Torben Frøstrup, Holst, René, Sørensen, Flemming Brandt
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenoma beta Catenin - genetics Cancer Cell Transformation, Neoplastic - genetics Clusters Colon Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Deregulation Epithelial cells Feasibility studies Female Gene Expression Regulation, Neoplastic Genetic aspects Humans In Situ Hybridization Invasiveness Lamina propria Male Medical research Medical screening MicroRNA MicroRNAs MicroRNAs - genetics miRNA Molecular Imaging Mucosa Multigene Family Mutation Neoplasm Grading Neoplasm Invasiveness Neoplasm Staging Pathology Phosphatase Polyps PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Reproducibility of Results Ribonucleic acid RNA Stroma Tumors
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