Absence of the Yeast Hsp31 Chaperones of the DJ-1 Superfamily Perturbs Cytoplasmic Protein Quality Control in Late Growth Phase

The Saccharomyces cerevisiae heat shock proteins Hsp31, Hsp32, Hsp33 and Hsp34 belong to the DJ-1/ThiJ/PfpI superfamily which includes the human protein DJ-1 (PARK7) as the most prominent member. Mutations in the DJ-1 gene are directly linked to autosomal recessive, early-onset Parkinson's dise...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140363-e0140363
Hauptverfasser:	Amm, Ingo, Norell, Derrick, Wolf, Dieter H
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Agglomeration Amino Acid Sequence Analysis Arginine Baking yeast Binding sites Biodegradation Cell Cycle Chaperones Degradation E coli Endoplasmic reticulum Enzymes Epistasis Epistasis, Genetic Fibrillation Gene expression Gene mutation Genomes Genomics Growth Heat shock proteins Heat-Shock Proteins - chemistry Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hsp70 protein Molecular Sequence Data Mutation Myc protein Oxidative stress PARK7 protein Physiology Protein folding Proteins Quality control Reactive oxygen species Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Studies Substrates Synuclein Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Unfolded Protein Response Yeast
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