Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver

Dopaminergic systems regulate the release of several hormones including growth hormone (GH), thyroid hormones, insulin, glucocorticoids and prolactin (PRL) that play significant roles in the regulation of various Cytochrome P450 (CYP) enzymes. The present study investigated the role of dopamine D2-r...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0128708-e0128708
Hauptverfasser:	Harkitis, P, Daskalopoulos, E P, Malliou, F, Lang, M A, Marselos, M, Fotopoulos, A, Albucharali, G, Konstandi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Aromatic compounds Benzo(a)pyrene Benzo(a)pyrene - chemistry Carcinogenicity Carcinogens Carcinogens - chemistry Control CYP1A2 protein Cytochrome Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 Cytochrome P-450 CYP1B1 - metabolism Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Cytochromes - metabolism Deactivation Dopamine Dopamine - genetics Dopamine D2 Receptor Antagonists - chemistry Dopamine D2 receptors Down-Regulation Drugs Environmental risk Enzymes Gene expression Gene Expression Profiling Gene Expression Regulation, Enzymologic Genes Glucocorticoids Glucocorticoids - metabolism Growth hormone Growth hormones Heat shock proteins Hepatocytes - metabolism Hormones Hsp90 protein Hydrocarbons Inactivation Insulin Insulin - metabolism Kinases Laboratory animals Liver Liver - drug effects Liver - metabolism Male Medical research Metabolism Metabolites Microsomes, Liver - metabolism Nuclear medicine Pathways Pharmacology Pollutants Prolactin Prolactin - metabolism Proteins Pyrene Rats Rats, Wistar Receptors Receptors, Aryl Hydrocarbon - metabolism Receptors, Dopamine D2 - metabolism Risk reduction Rodents Signal Transduction Studies Sulpiride Thyroid Thyroid hormones Thyroid Hormones - metabolism Toxicants Toxicity Toxicology Transduction
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