Plant Hormone Salicylic Acid Produced by a Malaria Parasite Controls Host Immunity and Cerebral Malaria Outcome

The apicomplexan parasite Toxoplasma gondii produces the plant hormone abscisic acid, but it is unclear if phytohormones are produced by the malaria parasite Plasmodium spp., the most important parasite of this phylum. Here, we report detection of salicylic acid, an immune-related phytohormone of la...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140559
Hauptverfasser:	Matsubara, Ryuma, Aonuma, Hiroka, Kojima, Mikiko, Tahara, Michiru, Andrabi, Syed Bilal Ahmad, Sakakibara, Hitoshi, Nagamune, Kisaburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscisic acid Acids Analysis Animals Animals, Genetically Modified Brain Cell culture Cytokines Cytokines - blood Cytokines - metabolism Deficient mutant Distribution Female Gene mutation Health aspects Humans Immune response Immunity Immunity - drug effects Interferon Interleukin 2 Lysates Malaria Malaria, Cerebral - immunology Malaria, Cerebral - metabolism Malaria, Cerebral - mortality Malaria, Cerebral - parasitology Mice Mutants NahG gene Parasites Patient outcomes Phytohormones Plant Growth Regulators - pharmacology Plant hormones Plasmodium Plasmodium berghei - metabolism Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - immunology Prostaglandin E2 Prostaglandins - blood Prostaglandins - metabolism Salicylic acid Salicylic Acid - pharmacology Vector-borne diseases
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