The Effect of Different Types of Musculoskeletal Injuries on Blood Concentration of Serum Amyloid A in Thoroughbred Racehorses
Training-induced muscle, skeletal and joint trauma may result in acute phase response reflected by the changes in the blood concentration of serum amyloid A (SAA) in racehorses. It remains yet unclear if such systemic reaction could be triggered by sport injuries and what is the impact of different...
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| creator | Turło, Agnieszka Cywińska, Anna Czopowicz, Michał Witkowski, Lucjan Niedźwiedź, Artur Słowikowska, Malwina Borowicz, Hieronim Jaśkiewicz, Anna Winnicka, Anna |
| description | Training-induced muscle, skeletal and joint trauma may result in acute phase response reflected by the changes in the blood concentration of serum amyloid A (SAA) in racehorses. It remains yet unclear if such systemic reaction could be triggered by sport injuries and what is the impact of different types of musculoskeletal trauma on SAA concentrations in racehorses. This study aimed to determine changes in the SAA blood concentration in racehorses with different types of injuries of musculoskeletal system.
The study involved 28 racehorses diagnosed after the race with bone fractures (n = 7), dorsal metacarpal disease (n = 11), joint trauma (n = 4) or tendon and muscle trauma (n = 6) and 28 healthy control racehorses. Serum samples were collected twice, between 1 and 4 days of the injury or succesful completion of the race. SAA concentration was measured using the commercial ELISA kit. Differences between mean SAA concentration in respective groups were analyzed using ANOVA and Tukey post-hoc test.
Mean SAA concentration within the first 4 days of the injury of muscle and tendon was significantly higher than in bone fractures, dorsal metacarpal disease, joint trauma or in the healthy horses (p |
| doi_str_mv | 10.1371/journal.pone.0140673 |
| format | Article |
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The study involved 28 racehorses diagnosed after the race with bone fractures (n = 7), dorsal metacarpal disease (n = 11), joint trauma (n = 4) or tendon and muscle trauma (n = 6) and 28 healthy control racehorses. Serum samples were collected twice, between 1 and 4 days of the injury or succesful completion of the race. SAA concentration was measured using the commercial ELISA kit. Differences between mean SAA concentration in respective groups were analyzed using ANOVA and Tukey post-hoc test.
Mean SAA concentration within the first 4 days of the injury of muscle and tendon was significantly higher than in bone fractures, dorsal metacarpal disease, joint trauma or in the healthy horses (p<0,001). There were no significant differences between the other groups.
Strain injuries of muscle and tendons can cause a moderate increase in SAA blood concentration in racehorses, reflecting the occurrence of the acute phase response. Similar reaction is not observed in the stress-related bone injuries.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0140673</identifier><identifier>PMID: 26466121</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amyloid ; Animal training ; Animals ; Arthritis ; Biomarkers ; Blood ; Blood levels ; Case-Control Studies ; Complications and side effects ; Cytokines ; Disease ; Enzyme-linked immunosorbent assay ; Epidemiology ; Fractures ; Genetic aspects ; Glycoproteins ; Health aspects ; Horse Diseases - blood ; Horse racing ; Horses ; Injuries ; Joint surgery ; Laboratories ; Life sciences ; Metacarpal ; Muscles ; Musculoskeletal diseases ; Musculoskeletal Diseases - veterinary ; Musculoskeletal system ; Pathology ; Racehorses ; Serum Amyloid A Protein ; Skeletal muscle ; Sports related injuries ; Tendons ; TNF inhibitors ; Trauma ; Tumor necrosis factor-TNF ; Ultrasonic imaging ; Variance analysis ; Veterinary medicine ; Wounds and Injuries - veterinary</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0140673-e0140673</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Turło et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Turło et al 2015 Turło et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-652ebbbb1aa1e7d2042eca10026624c66eb446743b1ee6f47fcd711e5a55d24d3</citedby><cites>FETCH-LOGICAL-c758t-652ebbbb1aa1e7d2042eca10026624c66eb446743b1ee6f47fcd711e5a55d24d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605491/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605491/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26466121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Reddy, Hemachandra</contributor><creatorcontrib>Turło, Agnieszka</creatorcontrib><creatorcontrib>Cywińska, Anna</creatorcontrib><creatorcontrib>Czopowicz, Michał</creatorcontrib><creatorcontrib>Witkowski, Lucjan</creatorcontrib><creatorcontrib>Niedźwiedź, Artur</creatorcontrib><creatorcontrib>Słowikowska, Malwina</creatorcontrib><creatorcontrib>Borowicz, Hieronim</creatorcontrib><creatorcontrib>Jaśkiewicz, Anna</creatorcontrib><creatorcontrib>Winnicka, Anna</creatorcontrib><title>The Effect of Different Types of Musculoskeletal Injuries on Blood Concentration of Serum Amyloid A in Thoroughbred Racehorses</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Training-induced muscle, skeletal and joint trauma may result in acute phase response reflected by the changes in the blood concentration of serum amyloid A (SAA) in racehorses. It remains yet unclear if such systemic reaction could be triggered by sport injuries and what is the impact of different types of musculoskeletal trauma on SAA concentrations in racehorses. This study aimed to determine changes in the SAA blood concentration in racehorses with different types of injuries of musculoskeletal system.
The study involved 28 racehorses diagnosed after the race with bone fractures (n = 7), dorsal metacarpal disease (n = 11), joint trauma (n = 4) or tendon and muscle trauma (n = 6) and 28 healthy control racehorses. Serum samples were collected twice, between 1 and 4 days of the injury or succesful completion of the race. SAA concentration was measured using the commercial ELISA kit. Differences between mean SAA concentration in respective groups were analyzed using ANOVA and Tukey post-hoc test.
Mean SAA concentration within the first 4 days of the injury of muscle and tendon was significantly higher than in bone fractures, dorsal metacarpal disease, joint trauma or in the healthy horses (p<0,001). There were no significant differences between the other groups.
Strain injuries of muscle and tendons can cause a moderate increase in SAA blood concentration in racehorses, reflecting the occurrence of the acute phase response. Similar reaction is not observed in the stress-related bone injuries.</description><subject>Amyloid</subject><subject>Animal training</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Case-Control Studies</subject><subject>Complications and side effects</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epidemiology</subject><subject>Fractures</subject><subject>Genetic aspects</subject><subject>Glycoproteins</subject><subject>Health aspects</subject><subject>Horse Diseases - blood</subject><subject>Horse racing</subject><subject>Horses</subject><subject>Injuries</subject><subject>Joint surgery</subject><subject>Laboratories</subject><subject>Life sciences</subject><subject>Metacarpal</subject><subject>Muscles</subject><subject>Musculoskeletal diseases</subject><subject>Musculoskeletal Diseases - veterinary</subject><subject>Musculoskeletal system</subject><subject>Pathology</subject><subject>Racehorses</subject><subject>Serum Amyloid A Protein</subject><subject>Skeletal muscle</subject><subject>Sports related injuries</subject><subject>Tendons</subject><subject>TNF inhibitors</subject><subject>Trauma</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ultrasonic imaging</subject><subject>Variance analysis</subject><subject>Veterinary medicine</subject><subject>Wounds and Injuries - veterinary</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0Fv0zAUxyMEYmPwDRBYQkJwaIkdx0kuk0oZUGlo0la4Wo790rg4cbETRC98dhyaTQ3ageQQ5_n3_9vv2S-KnuN4jpMMv9va3rXCzHe2hXmMacyy5EF0iouEzBiJk4dH45PoiffbOE6TnLHH0QlhlDFM8Gn0e10DuqgqkB2yFfqgw9BB26H1fgd-CH3pveyN9d_BQCcMWrXb3ulhrkXvjbUKLW0rg8SJTodYkNyA6xu0aPbGaoUWSLdoXVtn-01dOlDoWkgI_x780-hRJYyHZ-P3LPr68WK9_Dy7vPq0Wi4uZzJL827GUgJleLAQGDJFYkpAChzHhDFCJWNQUsoympQYgFU0q6TKMIZUpKkiVCVn0cuD7y5kwsfSeY4zQjDLMc4CsToQyoot3zndCLfnVmj-N2DdhgvXaWmAi5LhKldZKSimGeQiF1JJkbKyKopC5sHrfFytLxtQh-KYiel0ptU139ifnLI4pQUOBm9GA2d_9OA73mgvwRjRgu0P-y4Iw3RAX_2D3p_dSG1ESEC3lQ3rysGUL2iC05zkOQnU_B4qvAoaLcM9q3SITwRvJ4LAdPCr24jee766uf5_9urblH19xNYgTFd7a_rhgvkpSA-gdNZ7B9VdkXHMhza5rQYf2oSPbRJkL44P6E502xfJH82GDnE</recordid><startdate>20151014</startdate><enddate>20151014</enddate><creator>Turło, Agnieszka</creator><creator>Cywińska, Anna</creator><creator>Czopowicz, Michał</creator><creator>Witkowski, Lucjan</creator><creator>Niedźwiedź, Artur</creator><creator>Słowikowska, Malwina</creator><creator>Borowicz, Hieronim</creator><creator>Jaśkiewicz, Anna</creator><creator>Winnicka, Anna</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151014</creationdate><title>The Effect of Different Types of Musculoskeletal Injuries on Blood Concentration of Serum Amyloid A in Thoroughbred Racehorses</title><author>Turło, Agnieszka ; Cywińska, Anna ; Czopowicz, Michał ; Witkowski, Lucjan ; Niedźwiedź, Artur ; Słowikowska, Malwina ; Borowicz, Hieronim ; Jaśkiewicz, Anna ; Winnicka, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-652ebbbb1aa1e7d2042eca10026624c66eb446743b1ee6f47fcd711e5a55d24d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Amyloid</topic><topic>Animal training</topic><topic>Animals</topic><topic>Arthritis</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Case-Control Studies</topic><topic>Complications and side effects</topic><topic>Cytokines</topic><topic>Disease</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epidemiology</topic><topic>Fractures</topic><topic>Genetic aspects</topic><topic>Glycoproteins</topic><topic>Health aspects</topic><topic>Horse Diseases - blood</topic><topic>Horse racing</topic><topic>Horses</topic><topic>Injuries</topic><topic>Joint surgery</topic><topic>Laboratories</topic><topic>Life sciences</topic><topic>Metacarpal</topic><topic>Muscles</topic><topic>Musculoskeletal diseases</topic><topic>Musculoskeletal Diseases - veterinary</topic><topic>Musculoskeletal system</topic><topic>Pathology</topic><topic>Racehorses</topic><topic>Serum Amyloid A Protein</topic><topic>Skeletal muscle</topic><topic>Sports related injuries</topic><topic>Tendons</topic><topic>TNF inhibitors</topic><topic>Trauma</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ultrasonic imaging</topic><topic>Variance analysis</topic><topic>Veterinary medicine</topic><topic>Wounds and Injuries - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turło, Agnieszka</creatorcontrib><creatorcontrib>Cywińska, Anna</creatorcontrib><creatorcontrib>Czopowicz, Michał</creatorcontrib><creatorcontrib>Witkowski, Lucjan</creatorcontrib><creatorcontrib>Niedźwiedź, Artur</creatorcontrib><creatorcontrib>Słowikowska, Malwina</creatorcontrib><creatorcontrib>Borowicz, Hieronim</creatorcontrib><creatorcontrib>Jaśkiewicz, Anna</creatorcontrib><creatorcontrib>Winnicka, Anna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turło, Agnieszka</au><au>Cywińska, Anna</au><au>Czopowicz, Michał</au><au>Witkowski, Lucjan</au><au>Niedźwiedź, Artur</au><au>Słowikowska, Malwina</au><au>Borowicz, Hieronim</au><au>Jaśkiewicz, Anna</au><au>Winnicka, Anna</au><au>Reddy, Hemachandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Different Types of Musculoskeletal Injuries on Blood Concentration of Serum Amyloid A in Thoroughbred Racehorses</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-10-14</date><risdate>2015</risdate><volume>10</volume><issue>10</issue><spage>e0140673</spage><epage>e0140673</epage><pages>e0140673-e0140673</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Training-induced muscle, skeletal and joint trauma may result in acute phase response reflected by the changes in the blood concentration of serum amyloid A (SAA) in racehorses. It remains yet unclear if such systemic reaction could be triggered by sport injuries and what is the impact of different types of musculoskeletal trauma on SAA concentrations in racehorses. This study aimed to determine changes in the SAA blood concentration in racehorses with different types of injuries of musculoskeletal system.
The study involved 28 racehorses diagnosed after the race with bone fractures (n = 7), dorsal metacarpal disease (n = 11), joint trauma (n = 4) or tendon and muscle trauma (n = 6) and 28 healthy control racehorses. Serum samples were collected twice, between 1 and 4 days of the injury or succesful completion of the race. SAA concentration was measured using the commercial ELISA kit. Differences between mean SAA concentration in respective groups were analyzed using ANOVA and Tukey post-hoc test.
Mean SAA concentration within the first 4 days of the injury of muscle and tendon was significantly higher than in bone fractures, dorsal metacarpal disease, joint trauma or in the healthy horses (p<0,001). There were no significant differences between the other groups.
Strain injuries of muscle and tendons can cause a moderate increase in SAA blood concentration in racehorses, reflecting the occurrence of the acute phase response. Similar reaction is not observed in the stress-related bone injuries.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26466121</pmid><doi>10.1371/journal.pone.0140673</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2015-10, Vol.10 (10), p.e0140673-e0140673 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amyloid Animal training Animals Arthritis Biomarkers Blood Blood levels Case-Control Studies Complications and side effects Cytokines Disease Enzyme-linked immunosorbent assay Epidemiology Fractures Genetic aspects Glycoproteins Health aspects Horse Diseases - blood Horse racing Horses Injuries Joint surgery Laboratories Life sciences Metacarpal Muscles Musculoskeletal diseases Musculoskeletal Diseases - veterinary Musculoskeletal system Pathology Racehorses Serum Amyloid A Protein Skeletal muscle Sports related injuries Tendons TNF inhibitors Trauma Tumor necrosis factor-TNF Ultrasonic imaging Variance analysis Veterinary medicine Wounds and Injuries - veterinary |
| title | The Effect of Different Types of Musculoskeletal Injuries on Blood Concentration of Serum Amyloid A in Thoroughbred Racehorses |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T10%3A03%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Different%20Types%20of%20Musculoskeletal%20Injuries%20on%20Blood%20Concentration%20of%20Serum%20Amyloid%20A%20in%20Thoroughbred%20Racehorses&rft.jtitle=PloS%20one&rft.au=Tur%C5%82o,%20Agnieszka&rft.date=2015-10-14&rft.volume=10&rft.issue=10&rft.spage=e0140673&rft.epage=e0140673&rft.pages=e0140673-e0140673&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0140673&rft_dat=%3Cgale_plos_%3EA431582882%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1722168117&rft_id=info:pmid/26466121&rft_galeid=A431582882&rft_doaj_id=oai_doaj_org_article_ab61f8d7ba4147e8a8acdca56bf999c8&rfr_iscdi=true |