Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging
To study age-related changes in corneal deformation response to air-puff applanation tonometry. Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser based on the Schei...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-10, Vol.10 (10), p.e0140093-e0140093 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0140093 |
|---|---|
| container_issue | 10 |
| container_start_page | e0140093 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Rogowska, Marta E Iskander, D Robert |
| description | To study age-related changes in corneal deformation response to air-puff applanation tonometry.
Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser based on the Scheimpflug principle were performed on the left eye of each subject. Raw Scheimpflug images were used to extract changes in anterior and posterior corneal profiles, which were further modelled by an orthogonal series of Chebyshev polynomial functions. Time series of the polynomial coefficients of even order exhibited a dynamic behavior in which three distinct stages were recognized. A bilinear function was used to model the first and the third stage of corneal dynamics. Slope parameters of the bilinear fit were then tested between the two age groups using Wilcoxon rank sum test and two-way non-parametric ANOVA (Friedman) test.
Statistically significant changes (Wilcoxon test, P |
| doi_str_mv | 10.1371/journal.pone.0140093 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1721913747</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A431491232</galeid><doaj_id>oai_doaj_org_article_35c9310529a14a9c9ad8001b5c9724cc</doaj_id><sourcerecordid>A431491232</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-ca316d2233b58e0dc11fa3e3aae1e24535bca8b6b93a18980e302604803cc39c3</originalsourceid><addsrcrecordid>eNqNkl1v0zAUhiMEYmPwDxBEQkJw0eKvpPENUtXxUWnSxMa4tU6dk9STY5c4QYxfj7NmU4N2gXxh6_g5H379JslLSuaUL-iHa9-3Dux85x3OCRWESP4oOaaSs1nOCH98cD5KnoVwTUjGizx_mhyxXORELthx8m1Z4-wCLXRYpqstuBpDaly68q1DsOkpVr5toDPepac3DhqjQ3rVGWv-GFenl3qLptlVtq_TdQN1jD1PnlRgA74Y95Pk6vOn76uvs7PzL-vV8mymc8m6mQZO85IxzjdZgaTUlFbAkQMgRSYynm00FJt8IznQQhYEOWE5EQXhWnOp-Unyel93Z31QoxpB0QWjMgokFpFY74nSw7XataaB9kZ5MOo24NtaQdsZbVHxTEtOScYkUAFSSygLQugmhhdM6KHbx7Fbv2mw1Oi6Fuyk6PTGma2q_S8VhRY0G4Z5NxZo_c8eQ6caEzRaCw59fzs3E1SyQkb0zT_ow68bqRriA4yrfOyrh6JqKTgVkjLOIjV_gIqrxPiV0TqVifFJwvtJQmQ6_N3V0Ieg1pcX_8-e_5iybw_YbfRWtw3e9oOzwhQUe1C3PoQWq3uRKVGD8-_UUIPz1ej8mPbq8IPuk-6szv8C_t38Ew</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1721913747</pqid></control><display><type>article</type><title>Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Rogowska, Marta E ; Iskander, D Robert</creator><contributor>Acott, Ted S</contributor><creatorcontrib>Rogowska, Marta E ; Iskander, D Robert ; Acott, Ted S</creatorcontrib><description>To study age-related changes in corneal deformation response to air-puff applanation tonometry.
Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser based on the Scheimpflug principle were performed on the left eye of each subject. Raw Scheimpflug images were used to extract changes in anterior and posterior corneal profiles, which were further modelled by an orthogonal series of Chebyshev polynomial functions. Time series of the polynomial coefficients of even order exhibited a dynamic behavior in which three distinct stages were recognized. A bilinear function was used to model the first and the third stage of corneal dynamics. Slope parameters of the bilinear fit were then tested between the two age groups using Wilcoxon rank sum test and two-way non-parametric ANOVA (Friedman) test.
Statistically significant changes (Wilcoxon test, P<0.05) between the age groups were observed in the phase of the second applanation dynamics for the posterior corneal profile. In a two-way comparison, in which the corneal profile was used as a dependent variable, statistically significant changes (ANOVA/Friedman test, P = 0.017) between the groups were also observed for that phase.
Corneal biomechanics depend on age. The changes in corneal deformation dynamics, which correspond to mostly free return of the cornea to its original shape after the air pulse, indicate that the age related differences in corneal biomechanics are subtle but observable with high speed imaging.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0140093</identifier><identifier>PMID: 26460972</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Age Factors ; Analysis ; Analysis of Variance ; Biomechanics ; Biomedical engineering ; Cameras ; Chebyshev approximation ; Cornea ; Cornea - pathology ; Deformation ; Dependent variables ; Dynamics ; Epithelium ; Evaluation ; Female ; Functions (mathematics) ; High speed ; Humans ; Imaging, Three-Dimensional ; Male ; Mathematical functions ; Medical care ; Middle Aged ; Models, Biological ; Physiological aspects ; Physiology ; Polynomials ; Statistical analysis ; Statistical significance ; Time Factors ; United States ; Variance analysis ; Viscoelasticity ; Young Adult</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0140093-e0140093</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Rogowska, Iskander. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Rogowska, Iskander 2015 Rogowska, Iskander</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ca316d2233b58e0dc11fa3e3aae1e24535bca8b6b93a18980e302604803cc39c3</citedby><cites>FETCH-LOGICAL-c692t-ca316d2233b58e0dc11fa3e3aae1e24535bca8b6b93a18980e302604803cc39c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604157/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604157/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26460972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Acott, Ted S</contributor><creatorcontrib>Rogowska, Marta E</creatorcontrib><creatorcontrib>Iskander, D Robert</creatorcontrib><title>Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To study age-related changes in corneal deformation response to air-puff applanation tonometry.
Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser based on the Scheimpflug principle were performed on the left eye of each subject. Raw Scheimpflug images were used to extract changes in anterior and posterior corneal profiles, which were further modelled by an orthogonal series of Chebyshev polynomial functions. Time series of the polynomial coefficients of even order exhibited a dynamic behavior in which three distinct stages were recognized. A bilinear function was used to model the first and the third stage of corneal dynamics. Slope parameters of the bilinear fit were then tested between the two age groups using Wilcoxon rank sum test and two-way non-parametric ANOVA (Friedman) test.
Statistically significant changes (Wilcoxon test, P<0.05) between the age groups were observed in the phase of the second applanation dynamics for the posterior corneal profile. In a two-way comparison, in which the corneal profile was used as a dependent variable, statistically significant changes (ANOVA/Friedman test, P = 0.017) between the groups were also observed for that phase.
Corneal biomechanics depend on age. The changes in corneal deformation dynamics, which correspond to mostly free return of the cornea to its original shape after the air pulse, indicate that the age related differences in corneal biomechanics are subtle but observable with high speed imaging.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Analysis</subject><subject>Analysis of Variance</subject><subject>Biomechanics</subject><subject>Biomedical engineering</subject><subject>Cameras</subject><subject>Chebyshev approximation</subject><subject>Cornea</subject><subject>Cornea - pathology</subject><subject>Deformation</subject><subject>Dependent variables</subject><subject>Dynamics</subject><subject>Epithelium</subject><subject>Evaluation</subject><subject>Female</subject><subject>Functions (mathematics)</subject><subject>High speed</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Male</subject><subject>Mathematical functions</subject><subject>Medical care</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Polynomials</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Time Factors</subject><subject>United States</subject><subject>Variance analysis</subject><subject>Viscoelasticity</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAUhiMEYmPwDxBEQkJw0eKvpPENUtXxUWnSxMa4tU6dk9STY5c4QYxfj7NmU4N2gXxh6_g5H379JslLSuaUL-iHa9-3Dux85x3OCRWESP4oOaaSs1nOCH98cD5KnoVwTUjGizx_mhyxXORELthx8m1Z4-wCLXRYpqstuBpDaly68q1DsOkpVr5toDPepac3DhqjQ3rVGWv-GFenl3qLptlVtq_TdQN1jD1PnlRgA74Y95Pk6vOn76uvs7PzL-vV8mymc8m6mQZO85IxzjdZgaTUlFbAkQMgRSYynm00FJt8IznQQhYEOWE5EQXhWnOp-Unyel93Z31QoxpB0QWjMgokFpFY74nSw7XataaB9kZ5MOo24NtaQdsZbVHxTEtOScYkUAFSSygLQugmhhdM6KHbx7Fbv2mw1Oi6Fuyk6PTGma2q_S8VhRY0G4Z5NxZo_c8eQ6caEzRaCw59fzs3E1SyQkb0zT_ow68bqRriA4yrfOyrh6JqKTgVkjLOIjV_gIqrxPiV0TqVifFJwvtJQmQ6_N3V0Ieg1pcX_8-e_5iybw_YbfRWtw3e9oOzwhQUe1C3PoQWq3uRKVGD8-_UUIPz1ej8mPbq8IPuk-6szv8C_t38Ew</recordid><startdate>20151013</startdate><enddate>20151013</enddate><creator>Rogowska, Marta E</creator><creator>Iskander, D Robert</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151013</creationdate><title>Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging</title><author>Rogowska, Marta E ; Iskander, D Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ca316d2233b58e0dc11fa3e3aae1e24535bca8b6b93a18980e302604803cc39c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Analysis</topic><topic>Analysis of Variance</topic><topic>Biomechanics</topic><topic>Biomedical engineering</topic><topic>Cameras</topic><topic>Chebyshev approximation</topic><topic>Cornea</topic><topic>Cornea - pathology</topic><topic>Deformation</topic><topic>Dependent variables</topic><topic>Dynamics</topic><topic>Epithelium</topic><topic>Evaluation</topic><topic>Female</topic><topic>Functions (mathematics)</topic><topic>High speed</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Male</topic><topic>Mathematical functions</topic><topic>Medical care</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Polynomials</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><topic>Time Factors</topic><topic>United States</topic><topic>Variance analysis</topic><topic>Viscoelasticity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rogowska, Marta E</creatorcontrib><creatorcontrib>Iskander, D Robert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rogowska, Marta E</au><au>Iskander, D Robert</au><au>Acott, Ted S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-10-13</date><risdate>2015</risdate><volume>10</volume><issue>10</issue><spage>e0140093</spage><epage>e0140093</epage><pages>e0140093-e0140093</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To study age-related changes in corneal deformation response to air-puff applanation tonometry.
Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser based on the Scheimpflug principle were performed on the left eye of each subject. Raw Scheimpflug images were used to extract changes in anterior and posterior corneal profiles, which were further modelled by an orthogonal series of Chebyshev polynomial functions. Time series of the polynomial coefficients of even order exhibited a dynamic behavior in which three distinct stages were recognized. A bilinear function was used to model the first and the third stage of corneal dynamics. Slope parameters of the bilinear fit were then tested between the two age groups using Wilcoxon rank sum test and two-way non-parametric ANOVA (Friedman) test.
Statistically significant changes (Wilcoxon test, P<0.05) between the age groups were observed in the phase of the second applanation dynamics for the posterior corneal profile. In a two-way comparison, in which the corneal profile was used as a dependent variable, statistically significant changes (ANOVA/Friedman test, P = 0.017) between the groups were also observed for that phase.
Corneal biomechanics depend on age. The changes in corneal deformation dynamics, which correspond to mostly free return of the cornea to its original shape after the air pulse, indicate that the age related differences in corneal biomechanics are subtle but observable with high speed imaging.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26460972</pmid><doi>10.1371/journal.pone.0140093</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-10, Vol.10 (10), p.e0140093-e0140093 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1721913747 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Age Factors Analysis Analysis of Variance Biomechanics Biomedical engineering Cameras Chebyshev approximation Cornea Cornea - pathology Deformation Dependent variables Dynamics Epithelium Evaluation Female Functions (mathematics) High speed Humans Imaging, Three-Dimensional Male Mathematical functions Medical care Middle Aged Models, Biological Physiological aspects Physiology Polynomials Statistical analysis Statistical significance Time Factors United States Variance analysis Viscoelasticity Young Adult |
| title | Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T12%3A17%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-Related%20Changes%20in%20Corneal%20Deformation%20Dynamics%20Utilizing%20Scheimpflug%20Imaging&rft.jtitle=PloS%20one&rft.au=Rogowska,%20Marta%20E&rft.date=2015-10-13&rft.volume=10&rft.issue=10&rft.spage=e0140093&rft.epage=e0140093&rft.pages=e0140093-e0140093&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0140093&rft_dat=%3Cgale_plos_%3EA431491232%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1721913747&rft_id=info:pmid/26460972&rft_galeid=A431491232&rft_doaj_id=oai_doaj_org_article_35c9310529a14a9c9ad8001b5c9724cc&rfr_iscdi=true |