Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults
Postoperative delirium is one of the most common postoperative complications in geriatric patients. Mini-mental state examination (MMSE) assesses cognitive function in patients and is associated with postoperative delirium. However, whether there is an age-dependent relationship between preoperative...
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| description | Postoperative delirium is one of the most common postoperative complications in geriatric patients. Mini-mental state examination (MMSE) assesses cognitive function in patients and is associated with postoperative delirium. However, whether there is an age-dependent relationship between preoperative MMSE score and postoperative delirium remains unknown.
We therefore set out to investigate the association between preoperative MMSE score and postoperative delirium in young-old (≤80 year-old, 75.46±4.69 years, 27.0% male, n = 63) and old-old (>80 year-old, 84.51±3.46 years, 20.9% male, n = 67) participants, who had repairs of hip fractures under general anesthesia. The Confusion Assessment Method and Memorial Delirium Assessment Scale were administrated before surgery, and on the first, second and fourth days after surgery, to assess the incidence and severity of the delirium, respectively. A receiver operating characteristic curve analysis was used to calculate the optimal cutoff score of MMSE in predicting postoperative delirium.
Thirty-four (26.2%) of 130 patients (80.12±6.12 years, 23.8% male) developed postoperative delirium. Preoperative MMSE scores were negatively associated with higher incidences and greater severity of postoperative delirium. The optimal cutoff scores of MMSE associated with postoperative delirium for young-old and old-old participants were 18.4 and 21.4, with a sensitivity of 60% and 83.8%, and a specificity of 92.5% and 62.8%, respectively.
The data demonstrated the optimal cutoff score of MMSE associated with postoperative delirium in young-old adults might be lower than that in old-old adults. Pending further investigation, these findings suggest that the association between preoperative MMSE score and postoperative delirium is age-dependent. |
| doi_str_mv | 10.1371/journal.pone.0139879 |
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We therefore set out to investigate the association between preoperative MMSE score and postoperative delirium in young-old (≤80 year-old, 75.46±4.69 years, 27.0% male, n = 63) and old-old (>80 year-old, 84.51±3.46 years, 20.9% male, n = 67) participants, who had repairs of hip fractures under general anesthesia. The Confusion Assessment Method and Memorial Delirium Assessment Scale were administrated before surgery, and on the first, second and fourth days after surgery, to assess the incidence and severity of the delirium, respectively. A receiver operating characteristic curve analysis was used to calculate the optimal cutoff score of MMSE in predicting postoperative delirium.
Thirty-four (26.2%) of 130 patients (80.12±6.12 years, 23.8% male) developed postoperative delirium. Preoperative MMSE scores were negatively associated with higher incidences and greater severity of postoperative delirium. The optimal cutoff scores of MMSE associated with postoperative delirium for young-old and old-old participants were 18.4 and 21.4, with a sensitivity of 60% and 83.8%, and a specificity of 92.5% and 62.8%, respectively.
The data demonstrated the optimal cutoff score of MMSE associated with postoperative delirium in young-old adults might be lower than that in old-old adults. Pending further investigation, these findings suggest that the association between preoperative MMSE score and postoperative delirium is age-dependent.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0139879</identifier><identifier>PMID: 26460750</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Age ; Aged ; Aged, 80 and over ; Alzheimer's disease ; Analysis ; Anesthesia ; Bone surgery ; Cognitive ability ; Cognitive development ; Complications ; Data analysis ; Delirium ; Delirium - diagnosis ; Delirium - epidemiology ; Delirium - etiology ; Dementia ; Demography ; Evaluation ; Female ; Fractures ; Hip ; Hospitals ; Humans ; Hypotheses ; Incidence ; Maintenance ; Male ; Medical care ; Mental disorders ; Mental Status Schedule ; Patients ; Postoperative Care ; Postoperative Complications - diagnosis ; Postoperative Complications - epidemiology ; Preoperative Care ; Psychiatry ; Studies ; Surgery ; United States</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0139879-e0139879</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Wu et al 2015 Wu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e9e3285034b4ceb5576bc90876cd41323ffa64d82a83d70bb20ffc33720a0a4c3</citedby><cites>FETCH-LOGICAL-c692t-e9e3285034b4ceb5576bc90876cd41323ffa64d82a83d70bb20ffc33720a0a4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603675/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603675/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26460750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wei, Huafeng</contributor><creatorcontrib>Wu, Yujie</creatorcontrib><creatorcontrib>Shi, Zhongyong</creatorcontrib><creatorcontrib>Wang, Meijuan</creatorcontrib><creatorcontrib>Zhu, Yingbo</creatorcontrib><creatorcontrib>Li, Cheng</creatorcontrib><creatorcontrib>Li, Guodong</creatorcontrib><creatorcontrib>Marcantonio, Edward R</creatorcontrib><creatorcontrib>Xie, Zhongcong</creatorcontrib><creatorcontrib>Shen, Yuan</creatorcontrib><title>Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Postoperative delirium is one of the most common postoperative complications in geriatric patients. Mini-mental state examination (MMSE) assesses cognitive function in patients and is associated with postoperative delirium. However, whether there is an age-dependent relationship between preoperative MMSE score and postoperative delirium remains unknown.
We therefore set out to investigate the association between preoperative MMSE score and postoperative delirium in young-old (≤80 year-old, 75.46±4.69 years, 27.0% male, n = 63) and old-old (>80 year-old, 84.51±3.46 years, 20.9% male, n = 67) participants, who had repairs of hip fractures under general anesthesia. The Confusion Assessment Method and Memorial Delirium Assessment Scale were administrated before surgery, and on the first, second and fourth days after surgery, to assess the incidence and severity of the delirium, respectively. A receiver operating characteristic curve analysis was used to calculate the optimal cutoff score of MMSE in predicting postoperative delirium.
Thirty-four (26.2%) of 130 patients (80.12±6.12 years, 23.8% male) developed postoperative delirium. Preoperative MMSE scores were negatively associated with higher incidences and greater severity of postoperative delirium. The optimal cutoff scores of MMSE associated with postoperative delirium for young-old and old-old participants were 18.4 and 21.4, with a sensitivity of 60% and 83.8%, and a specificity of 92.5% and 62.8%, respectively.
The data demonstrated the optimal cutoff score of MMSE associated with postoperative delirium in young-old adults might be lower than that in old-old adults. Pending further investigation, these findings suggest that the association between preoperative MMSE score and postoperative delirium is age-dependent.</description><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer's disease</subject><subject>Analysis</subject><subject>Anesthesia</subject><subject>Bone surgery</subject><subject>Cognitive ability</subject><subject>Cognitive development</subject><subject>Complications</subject><subject>Data analysis</subject><subject>Delirium</subject><subject>Delirium - diagnosis</subject><subject>Delirium - epidemiology</subject><subject>Delirium - etiology</subject><subject>Dementia</subject><subject>Demography</subject><subject>Evaluation</subject><subject>Female</subject><subject>Fractures</subject><subject>Hip</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Incidence</subject><subject>Maintenance</subject><subject>Male</subject><subject>Medical care</subject><subject>Mental disorders</subject><subject>Mental Status Schedule</subject><subject>Patients</subject><subject>Postoperative Care</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - epidemiology</subject><subject>Preoperative Care</subject><subject>Psychiatry</subject><subject>Studies</subject><subject>Surgery</subject><subject>United States</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01vEzEQhlcIREvhHyCwhITKIcFf-3WpFLUFIrUKIoDEBcvrnU0cOetge1v49zjJtsqiHpAPY9nPvPa89iTJS4LHhOXk_cp2rpVmvLEtjDFhZZGXj5JjUjI6yihmjw_mR8kz71cYp6zIsqfJEc14hvMUHyc_L3TTgIM2oOvr-SWaK-sATT2aeG-VlgFqdKvDEn22PtgNOBn0DaALMNrpbo10i37Yrl2MZqZGsq1RjLv5pO5M8M-TJ400Hl708ST59uHy6_mn0dXs4_R8cjVSWUnDCEpgtEgx4xVXUKVpnlWqxEWeqZoTRlnTyIzXBZUFq3NcVRQ3jWIsp1hiyRU7SV7vdTfGetFb4wXJKSkJwzSLxHRP1FauxMbptXR_hJVa7BasWwjpglYGRCoVJQw4rQrgXKlKcQnAOC0aiUuaR62z_rSuWkOtontOmoHocKfVS7GwNyK6zrI8jQKnvYCzvzrwQay1V2CMbMF2u3tTHt-NFRF98w_6cHU9tZCxAN02Np6rtqJiwhnhJaEYR2r8ABVHDWut4j9qdFwfJLwbJEQmwO-wkJ33Yjr_8v_s7PuQfXvALkGasPTWdEHb1g9BvgeVs947aO5NJlhs2-DODbFtA9G3QUx7dfhA90l3_579BazaAKM</recordid><startdate>20151013</startdate><enddate>20151013</enddate><creator>Wu, Yujie</creator><creator>Shi, Zhongyong</creator><creator>Wang, Meijuan</creator><creator>Zhu, Yingbo</creator><creator>Li, Cheng</creator><creator>Li, Guodong</creator><creator>Marcantonio, Edward R</creator><creator>Xie, Zhongcong</creator><creator>Shen, Yuan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151013</creationdate><title>Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults</title><author>Wu, Yujie ; Shi, Zhongyong ; Wang, Meijuan ; Zhu, Yingbo ; Li, Cheng ; Li, Guodong ; Marcantonio, Edward R ; Xie, Zhongcong ; Shen, Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-e9e3285034b4ceb5576bc90876cd41323ffa64d82a83d70bb20ffc33720a0a4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adults</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer's disease</topic><topic>Analysis</topic><topic>Anesthesia</topic><topic>Bone surgery</topic><topic>Cognitive ability</topic><topic>Cognitive development</topic><topic>Complications</topic><topic>Data analysis</topic><topic>Delirium</topic><topic>Delirium - diagnosis</topic><topic>Delirium - epidemiology</topic><topic>Delirium - etiology</topic><topic>Dementia</topic><topic>Demography</topic><topic>Evaluation</topic><topic>Female</topic><topic>Fractures</topic><topic>Hip</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Incidence</topic><topic>Maintenance</topic><topic>Male</topic><topic>Medical care</topic><topic>Mental disorders</topic><topic>Mental Status Schedule</topic><topic>Patients</topic><topic>Postoperative Care</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - epidemiology</topic><topic>Preoperative Care</topic><topic>Psychiatry</topic><topic>Studies</topic><topic>Surgery</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yujie</creatorcontrib><creatorcontrib>Shi, Zhongyong</creatorcontrib><creatorcontrib>Wang, Meijuan</creatorcontrib><creatorcontrib>Zhu, Yingbo</creatorcontrib><creatorcontrib>Li, Cheng</creatorcontrib><creatorcontrib>Li, Guodong</creatorcontrib><creatorcontrib>Marcantonio, Edward R</creatorcontrib><creatorcontrib>Xie, Zhongcong</creatorcontrib><creatorcontrib>Shen, Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yujie</au><au>Shi, Zhongyong</au><au>Wang, Meijuan</au><au>Zhu, Yingbo</au><au>Li, Cheng</au><au>Li, Guodong</au><au>Marcantonio, Edward R</au><au>Xie, Zhongcong</au><au>Shen, Yuan</au><au>Wei, Huafeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-10-13</date><risdate>2015</risdate><volume>10</volume><issue>10</issue><spage>e0139879</spage><epage>e0139879</epage><pages>e0139879-e0139879</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Postoperative delirium is one of the most common postoperative complications in geriatric patients. Mini-mental state examination (MMSE) assesses cognitive function in patients and is associated with postoperative delirium. However, whether there is an age-dependent relationship between preoperative MMSE score and postoperative delirium remains unknown.
We therefore set out to investigate the association between preoperative MMSE score and postoperative delirium in young-old (≤80 year-old, 75.46±4.69 years, 27.0% male, n = 63) and old-old (>80 year-old, 84.51±3.46 years, 20.9% male, n = 67) participants, who had repairs of hip fractures under general anesthesia. The Confusion Assessment Method and Memorial Delirium Assessment Scale were administrated before surgery, and on the first, second and fourth days after surgery, to assess the incidence and severity of the delirium, respectively. A receiver operating characteristic curve analysis was used to calculate the optimal cutoff score of MMSE in predicting postoperative delirium.
Thirty-four (26.2%) of 130 patients (80.12±6.12 years, 23.8% male) developed postoperative delirium. Preoperative MMSE scores were negatively associated with higher incidences and greater severity of postoperative delirium. The optimal cutoff scores of MMSE associated with postoperative delirium for young-old and old-old participants were 18.4 and 21.4, with a sensitivity of 60% and 83.8%, and a specificity of 92.5% and 62.8%, respectively.
The data demonstrated the optimal cutoff score of MMSE associated with postoperative delirium in young-old adults might be lower than that in old-old adults. Pending further investigation, these findings suggest that the association between preoperative MMSE score and postoperative delirium is age-dependent.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26460750</pmid><doi>10.1371/journal.pone.0139879</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Age Aged Aged, 80 and over Alzheimer's disease Analysis Anesthesia Bone surgery Cognitive ability Cognitive development Complications Data analysis Delirium Delirium - diagnosis Delirium - epidemiology Delirium - etiology Dementia Demography Evaluation Female Fractures Hip Hospitals Humans Hypotheses Incidence Maintenance Male Medical care Mental disorders Mental Status Schedule Patients Postoperative Care Postoperative Complications - diagnosis Postoperative Complications - epidemiology Preoperative Care Psychiatry Studies Surgery United States |
| title | Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T11%3A12%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Different%20MMSE%20Score%20Is%20Associated%20with%20Postoperative%20Delirium%20in%20Young-Old%20and%20Old-Old%20Adults&rft.jtitle=PloS%20one&rft.au=Wu,%20Yujie&rft.date=2015-10-13&rft.volume=10&rft.issue=10&rft.spage=e0139879&rft.epage=e0139879&rft.pages=e0139879-e0139879&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0139879&rft_dat=%3Cgale_plos_%3EA431491200%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1721913026&rft_id=info:pmid/26460750&rft_galeid=A431491200&rft_doaj_id=oai_doaj_org_article_5ac213e42b8e44ccbc4aee3428fa0927&rfr_iscdi=true |