Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome

To date, mitochondrial DNA polymerase γ (POLG) is the only polymerase known to be present in mammalian mitochondria. A dogma in the mitochondria field is that there is no other polymerase present in the mitochondria of mammalian cells. Here we demonstrate localization of REV3 DNA polymerase in the m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140409
Hauptverfasser:	Singh, Bhupendra, Li, Xiurong, Owens, Kjerstin M, Vanniarajan, Ayyasamy, Liang, Ping, Singh, Keshav K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Amino Acid Sequence Analysis Animals Biotechnology Breast cancer Breast Neoplasms - pathology Cancer Carcinogenesis - pathology Cell growth Cell Line, Tumor Cell migration Cell proliferation Cell survival Cytoprotection Deactivation Deoxyribonucleic acid DNA DNA Damage DNA polymerase DNA Polymerase gamma DNA polymerases DNA repair DNA, Mitochondrial - genetics DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism DNA-directed DNA polymerase DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - metabolism Female Fibroblasts Genetics Genome, Mitochondrial Genomes HEK293 Cells HeLa Cells Humans Inactivation Invasiveness Localization Mammalian cells Mammals Membrane potential Mice Mitochondria Mitochondria - enzymology Mitochondrial DNA Molecular Sequence Data Mutagenesis Mutation NIH 3T3 Cells Oxidative Phosphorylation Protein Binding Protein Transport Proteins Saccharomyces cerevisiae Tumor cell lines Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!