Different Dynamics for IgG and IgA Memory B Cells in Adolescents following a Meningococcal Serogroup C Tetanus Toxoid Conjugate Booster Vaccination Nine Years after Priming: A Role for Priming Age?

Antibody levels wane rapidly after Meningococcal serogroup C conjugate (MenCC) vaccination in young children, rendering the need for an adolescent booster dose. It is not clear whether circulating memory B cells are associated with persistence of MenC-specific antibody levels. Measurement of MenC-sp...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0138665-e0138665
Hauptverfasser:	Stoof, Susanne P, Buisman, Anne-Marie, van Rooijen, Debbie M, Boonacker, Rianne, van der Klis, Fiona R M, Sanders, Elisabeth A M, Berbers, Guy A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Age Aging - immunology Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antibodies, Bacterial - metabolism Antigens B-Lymphocytes - immunology Child Children Correlation Disease control Health aspects Health care Humans Immunization, Secondary Immunoassay Immunoglobulin A Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin A - metabolism Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunologic Memory Immunological memory Immunology Infectious diseases Lymphocytes B Measurement methods Memory cells Meningococcal Vaccines - immunology Neisseria meningitidis Neisseria meningitidis, Serogroup C - immunology Physiological aspects Priming Proteins Public health Saliva Saliva - metabolism Systematic review Teenagers Tetanus Vaccination Vaccines
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