Mitochondrial Damage-Associated Molecular Patterns (MTDs) Are Released during Hepatic Ischemia Reperfusion and Induce Inflammatory Responses

Ischemia / reperfusion injury (IRI) during the course of liver transplantation enhances the immunogenicity of allografts and thus impacts overall graft outcome. This sterile inflammatory insult is known to activate innate immunity and propagate organ damage through the recognition of damage-associat...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140105
Hauptverfasser:	Hu, Qianni, Wood, Caroline Ruth, Cimen, Sanem, Venkatachalam, Ananda Baskaran, Alwayn, Ian Patrick Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Analgesics Animal models Animals Apoptosis Autophagy Biocompatibility Biomarkers - metabolism Cell culture Cell death Cell Line Cell Survival Coculture Techniques Cold Cytokines Cytokines - metabolism Damage patterns Deoxyribonucleic acid Development and progression DNA DNA, Mitochondrial - metabolism Genetic aspects Hepatocytes Hepatocytes - metabolism Hepatocytes - pathology Hepatology Humans Hypoxia Immunity Immunogenicity Immunology Inflammation Inflammation - metabolism Injuries Innate immunity Interleukin 10 Interleukin 6 Ischemia Ischemia - metabolism Ischemia - pathology Laboratory animals Liver Liver - blood supply Liver - metabolism Liver - pathology Liver transplantation Liver Transplantation - adverse effects Liver transplants Male Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA Moisture content Pathogenesis Pattern recognition Physiological aspects Rats Reperfusion Reperfusion injury Reperfusion Injury - metabolism Risk factors Rodents Surgery Transplantation Transplants & implants Trauma Tumor necrosis factor-TNF Tumor necrosis factor-α
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