Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone

Genome Wide Association Studies suggest that Wnt16 is an important contributor to the mechanisms controlling bone mineral density, cortical thickness, bone strength and ultimately fracture risk. Wnt16 acts on osteoblasts and osteoclasts and, in cortical bone, is predominantly derived from osteoblast...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140260-e0140260
Hauptverfasser:	Todd, Henry, Galea, Gabriel L, Meakin, Lee B, Delisser, Peter J, Lanyon, Lance E, Windahl, Sara H, Price, Joanna S
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Age Aging Aging - metabolism Animals Biocompatibility Biomedical materials Bone (cortical) Bone density Bone loss Bone marrow Bone mass Bone mineral density Bone strength Cell and Molecular Biology Cell- och molekylärbiologi Cooperation CORTICAL BONE Estrogen Receptor alpha - metabolism Estrogens Estrogens - metabolism Estrogens - pharmacology Female FEMALE MICE Females Gene Expression Regulation - drug effects GENE-EXPRESSION Genetic aspects GENOME-WIDE Genomes KAPPA-B Kidneys LOAD-BEARING Male MALE-MICE Males Mechanical loading Mechanical properties Mechanical unloading Medical research Mice Mice, Inbred C57BL MINERAL DENSITY Mutation Nutrition research Osteoblasts Osteoclasts OSTEOGENIC Osteoporosis Osteoporosis - genetics Osteoporosis - metabolism Osteoporosis - physiopathology Ovariectomy Physiological aspects RECEPTOR-ALPHA RESPONSE Risk factors Rodents Sex hormones Tamoxifen Tibia Tibia - drug effects Tibia - metabolism Tibia - physiopathology Unloading Weight-Bearing Wnt proteins Wnt Proteins - genetics Wnt Proteins - metabolism
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