Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii

Toxoplasma gondii has evolved a number of strategies to evade immune responses in its many hosts. Previous genetic mapping of crosses between clonal type 1, 2, and 3 strains of T. gondii, which are prevalent in Europe and North America, identified two rhoptry proteins, ROP5 and ROP18, that function...

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Veröffentlicht in:	PLoS genetics 2015-08, Vol.11 (8), p.e1005434-e1005434
Hauptverfasser:	Behnke, Michael S, Khan, Asis, Lauron, Elvin J, Jimah, John R, Wang, Qiuling, Tolia, Niraj H, Sibley, L David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Animals, Outbred Strains Bacterial proteins Crystal structure DNA Copy Number Variations Genes Genetic aspects Health aspects Laboratories Molecular Sequence Data Parasites Phylogenetics Phylogeny Protein Interaction Domains and Motifs Proteins Protozoan Proteins - chemistry Protozoan Proteins - genetics Quantitative Trait Loci Rodent Diseases - parasitology Rodents South America Toxoplasma Toxoplasma - genetics Toxoplasma - pathogenicity Toxoplasmosis, Animal - parasitology Virulence (Microbiology) Virulence - genetics Virulence Factors - genetics
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