YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is observed in several types of human cancers. Here we investigated its genomic binding landscape in YAP1-activated cancer cells, a...

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Veröffentlicht in:	PLoS genetics 2015-08, Vol.11 (8), p.e1005465-e1005465
Hauptverfasser:	Stein, Claudia, Bardet, Anaïs Flore, Roma, Guglielmo, Bergling, Sebastian, Clay, Ieuan, Ruchti, Alexandra, Agarinis, Claudia, Schmelzle, Tobias, Bouwmeester, Tewis, Schübeler, Dirk, Bauer, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adaptor Proteins, Signal Transducing - physiology Base Sequence Binding Sites Cancer Cell Line, Tumor Consensus Sequence DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Experiments Gene amplification Gene expression Genetic transcription Genome-wide association studies Genomes Histones - metabolism Humans Laboratories Nuclear Proteins - metabolism Observations Phosphoproteins - physiology Protein Binding Protein Processing, Post-Translational Rodents Standard deviation Transcription factors Transcription Factors - metabolism Transcriptional Activation Transcriptome
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