Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans

Iron is a key pathogenic determinant of many infectious diseases. Hepcidin, the hormone responsible for governing systemic iron homeostasis, is widely hypothesized to represent a key component of nutritional immunity through regulating the accessibility of iron to invading microorganisms during infe...

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Veröffentlicht in:PLoS neglected tropical diseases 2015-09, Vol.9 (9), p.e0004029-e0004029
Hauptverfasser: Darton, Thomas C, Blohmke, Christoph J, Giannoulatou, Eleni, Waddington, Claire S, Jones, Claire, Sturges, Pamela, Webster, Craig, Drakesmith, Hal, Pollard, Andrew J, Armitage, Andrew E
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Sprache:eng
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