Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal

The continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global outbreak of extensively drug-resistant (XDR) tuberculosis (TB) identified in Tugela Ferry, KwaZulu-Natal, South Africa, in 2005 that continues tod...

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Veröffentlicht in:	PLoS medicine 2015-09, Vol.12 (9), p.e1001880-e1001880
Hauptverfasser:	Cohen, Keira A, Abeel, Thomas, Manson McGuire, Abigail, Desjardins, Christopher A, Munsamy, Vanisha, Shea, Terrance P, Walker, Bruce J, Bantubani, Nonkqubela, Almeida, Deepak V, Alvarado, Lucia, Chapman, Sinéad B, Mvelase, Nomonde R, Duffy, Eamon Y, Fitzgerald, Michael G, Govender, Pamla, Gujja, Sharvari, Hamilton, Susanna, Howarth, Clinton, Larimer, Jeffrey D, Maharaj, Kashmeel, Pearson, Matthew D, Priest, Margaret E, Zeng, Qiandong, Padayatchi, Nesri, Grosset, Jacques, Young, Sarah K, Wortman, Jennifer, Mlisana, Koleka P, O'Donnell, Max R, Birren, Bruce W, Bishai, William R, Pym, Alexander S, Earl, Ashlee M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics Antitubercular Agents - pharmacology Cloning Datasets Disease Outbreaks DNA sequencing Drug resistance Drug resistance in microorganisms Epidemics Extensively Drug-Resistant Tuberculosis - drug therapy Extensively Drug-Resistant Tuberculosis - epidemiology Extensively Drug-Resistant Tuberculosis - genetics Female Genetic aspects Genome, Bacterial Genomes Humans Male Methods Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Nucleotide sequencing Public health Researchers Sequence Analysis, DNA South Africa - epidemiology Studies Tuberculosis
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