Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter mean life span. In contrast, mice lacking...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0140292-e0140292
Hauptverfasser:	Aumailley, Lucie, Garand, Chantal, Dubois, Marie Julie, Johnson, F Brad, Marette, André, Lebel, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Age Aging Amino acids Analysis Animals Autophagy Blood Cardiovascular disease Cardiovascular diseases Cell death Cells, Cultured Chains Cytokines Deoxyribonucleic acid Diabetes DNA DNA helicase DNA methylation Embryo fibroblasts Embryos Endoplasmic reticulum Endoplasmic Reticulum - enzymology Epigenetics Extracellular matrix Female Fibroblasts Gene mutation Genetic aspects Genotype & phenotype Health risks Hydroxyproline Inflammation Interleukin 10 Interleukin 18 Laboratory animals Life span Liver Male Markers Mass spectrometry Mass spectroscopy Medicine Metabolism Metabolites Metabolomics Mice Mice, Inbred C57BL Mice, Knockout Morphology Mutants Mutation Organelles Oxidative Stress Phagocytosis Phenotype Phenotypes Physiology Plasminogen activator inhibitors Protein Transport Proteins Reactive Oxygen Species - metabolism RecQ Helicases - genetics RecQ protein Risk factors Rodents Tissue analysis Vascular system Werner syndrome Werner Syndrome - blood Werner Syndrome - enzymology Werner Syndrome - genetics Werner Syndrome Helicase Werner's syndrome WRN protein
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