A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide

Tissue injury and infection trigger innate immune responses. However, dysregulation may result in chronic inflammation and is commonly treated with corticosteroids and non-steroidal anti-inflammatory drugs. Unfortunately, long-term administration of both therapeutic classes can cause unwanted side e...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0137286
Hauptverfasser:	Wittmann, Christine, Reischl, Markus, Shah, Asmi H, Kronfuss, Eva, Mikut, Ralf, Liebel, Urban, Grabher, Clemens
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Apoptosis Automation Cells, Cultured Chronic infection Computer science Copper Copper Sulfate - toxicity Corticoids Corticosteroids Danio rerio Drug Repositioning - methods Drugs Free Radical Scavengers - pharmacology Gene Knockdown Techniques Guanylate cyclase Guanylate Cyclase - metabolism Immune response Immunomodulation Immunosuppressive agents In vivo methods and tests Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation Mediators - pharmacology Innate immunity Internet Kinases Larva - drug effects Larvae Leukocytes Leukocytes - immunology Libraries Medical screening Morpholinos - genetics Mucous Membrane - drug effects Mucous Membrane - injuries Nervous system Neurosciences Nitric oxide Nitric Oxide - pharmacology Nitric Oxide Synthase Type I - genetics Nitric Oxide Synthase Type II - genetics Nonsteroidal anti-inflammatory drugs Oxidative stress Peripheral Nervous System - drug effects Protein S Receptors, Cytoplasmic and Nuclear - metabolism Screening Side effects Soluble Guanylyl Cyclase Spinal cord Toxicology Zebrafish
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