In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem

Infections caused by multidrug resistant (MDR) bacteria are a major concern worldwide. Changes in membrane permeability, including decreased influx and/or increased efflux of antibiotics, are known as key contributors of bacterial MDR. Therefore, it is of critical importance to understand molecular...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0138828-e0138828
Hauptverfasser:	Philippe, Nadège, Maigre, Laure, Santini, Sébastien, Pinet, Elizabeth, Claverie, Jean-Michel, Davin-Régli, Anne-Véronique, Pagès, Jean-Marie, Masi, Muriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerogenes Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Antimicrobial agents Bacteria Bacterial infections Cell Membrane Permeability Chemotherapy Clinical isolates Complications and side effects Cystic fibrosis Dosage and administration Drug resistance Drug Resistance, Multiple, Bacterial - genetics Drug therapy E coli Efflux Enterobacter aerogenes Enterobacter aerogenes - drug effects Enterobacter aerogenes - genetics Enterobacter cloacae Enterobacteriaceae Enterobacteriaceae infections Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - microbiology Escherichia coli Evolution Evolution, Molecular Genes Genetic aspects Genome, Bacterial Genomes Genotypes Hospitals Humans Imipenem Imipenem - pharmacology Imipenem - therapeutic use Infections Kinases Klebsiella pneumoniae Membrane permeability Microbial drug resistance Molecular modelling Molecular Sequence Data Multidrug resistance Multidrug resistant organisms Mutation Nosocomial infection Nosocomial infections Outer membrane proteins Patients Permeability Phenotypes Porins Pseudomonas aeruginosa Sequence Analysis, DNA Stress response Transcription
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