Endovascular Management of Post-Irradiated Carotid Blowout Syndrome

To retrospectively evaluate the clinical and technical factors related to the outcomes of endovascular management in patients with head-and-neck cancers associated with post-irradiated carotid blowout syndrome (PCBS). Between 2000 and 2013, 96 patients with PCBS underwent endovascular management. Th...

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Veröffentlicht in:PloS one 2015-10, Vol.10 (10), p.e0139821-e0139821
Hauptverfasser: Chang, Feng-Chi, Luo, Chao-Bao, Lirng, Jiing-Feng, Lin, Chung-Jung, Lee, Han-Jui, Wu, Chih-Chun, Hung, Sheng-Che, Guo, Wan-Yuo
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container_title PloS one
container_volume 10
creator Chang, Feng-Chi
Luo, Chao-Bao
Lirng, Jiing-Feng
Lin, Chung-Jung
Lee, Han-Jui
Wu, Chih-Chun
Hung, Sheng-Che
Guo, Wan-Yuo
description To retrospectively evaluate the clinical and technical factors related to the outcomes of endovascular management in patients with head-and-neck cancers associated with post-irradiated carotid blowout syndrome (PCBS). Between 2000 and 2013, 96 patients with PCBS underwent endovascular management. The 40 patients with the pathological lesions located in the external carotid artery were classified as group 1 and were treated with embolization. The other 56 patients with the pathological lesions located in the trunk of the carotid artery were divided into 2 groups as follows: group 2A comprised the 38 patients treated with embolization, and group 2B comprised the 18 patients treated with stent-graft placement. Fisher's exact test was used to examine endovascular methods, clinical severities, and postprocedural clinical diseases as predictors of outcomes. Technical success and immediate hemostasis were achieved in all patients. The results according to endovascular methods (group 1 vs 2A vs 2B) were as follows: technical complication (1/40[2.5%] vs 9/38[23.7%] vs 9/18[50.0%], P = 0.0001); rebleeding (14/40[35.0%] vs 5/38[13.2%] vs 7/18[38.9%]), P = 0.0435). The results according to clinical severity (acute vs ongoing PCBS) were as follows: technical complication (15/47[31.9%] vs 4/49[8.2%], P = 0.0035); rebleeding (18/47[38.3%] vs 8/49[16.3%], P = 0.0155). The results according to post-procedural clinical disease (regressive vs progressive change) were as follows: alive (14/21[66.7%] vs 8/75[10.7%], P
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Between 2000 and 2013, 96 patients with PCBS underwent endovascular management. The 40 patients with the pathological lesions located in the external carotid artery were classified as group 1 and were treated with embolization. The other 56 patients with the pathological lesions located in the trunk of the carotid artery were divided into 2 groups as follows: group 2A comprised the 38 patients treated with embolization, and group 2B comprised the 18 patients treated with stent-graft placement. Fisher's exact test was used to examine endovascular methods, clinical severities, and postprocedural clinical diseases as predictors of outcomes. Technical success and immediate hemostasis were achieved in all patients. The results according to endovascular methods (group 1 vs 2A vs 2B) were as follows: technical complication (1/40[2.5%] vs 9/38[23.7%] vs 9/18[50.0%], P = 0.0001); rebleeding (14/40[35.0%] vs 5/38[13.2%] vs 7/18[38.9%]), P = 0.0435). The results according to clinical severity (acute vs ongoing PCBS) were as follows: technical complication (15/47[31.9%] vs 4/49[8.2%], P = 0.0035); rebleeding (18/47[38.3%] vs 8/49[16.3%], P = 0.0155). The results according to post-procedural clinical disease (regressive vs progressive change) were as follows: alive (14/21[66.7%] vs 8/75[10.7%], P&lt;0.0001); survival time (34.1±30.6[0.3-110] vs 3.6±4.0[0.07-22] months, P&lt;0.0001). The outcomes of endovascular management of PCBS can be improved by taking embolization as a prior way of treatment, performing endovascular intervention in slight clinical severity and aggressive management of the post-procedural clinical disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0139821</identifier><identifier>PMID: 26439632</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aneurysms ; Blood Vessel Prosthesis Implantation ; Cardiovascular system ; Care and treatment ; Carotid arteries ; Carotid artery ; Carotid Artery Diseases - etiology ; Carotid Artery Diseases - therapy ; Carotid Artery, External - surgery ; Consent ; Disease control ; Embolization ; Embolization, Therapeutic - methods ; Endovascular Procedures - methods ; Female ; Head &amp; neck cancer ; Head and neck cancer ; Head and Neck Neoplasms - complications ; Hemostasis ; Hemostatics ; Hospitals ; Humans ; Implants ; Lesions ; Life assessment ; Male ; Management ; Medicine ; Methods ; Middle Aged ; Neck ; Patient outcomes ; Patients ; Polyvinyl alcohol ; Retrospective Studies ; Stents ; Surgical implants ; Therapeutic embolization ; Treatment Outcome ; Tumors ; Vascular diseases ; Vascular surgery</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0139821-e0139821</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Chang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Chang et al 2015 Chang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2edd70d77417a43f05f663c044e20f285fd5b5e1db4005b8d41335692e08c5143</citedby><cites>FETCH-LOGICAL-c692t-2edd70d77417a43f05f663c044e20f285fd5b5e1db4005b8d41335692e08c5143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595276/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595276/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2097,2916,23848,27906,27907,53773,53775,79350,79351</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26439632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Arruda, Valder R.</contributor><creatorcontrib>Chang, Feng-Chi</creatorcontrib><creatorcontrib>Luo, Chao-Bao</creatorcontrib><creatorcontrib>Lirng, Jiing-Feng</creatorcontrib><creatorcontrib>Lin, Chung-Jung</creatorcontrib><creatorcontrib>Lee, Han-Jui</creatorcontrib><creatorcontrib>Wu, Chih-Chun</creatorcontrib><creatorcontrib>Hung, Sheng-Che</creatorcontrib><creatorcontrib>Guo, Wan-Yuo</creatorcontrib><title>Endovascular Management of Post-Irradiated Carotid Blowout Syndrome</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To retrospectively evaluate the clinical and technical factors related to the outcomes of endovascular management in patients with head-and-neck cancers associated with post-irradiated carotid blowout syndrome (PCBS). 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The results according to clinical severity (acute vs ongoing PCBS) were as follows: technical complication (15/47[31.9%] vs 4/49[8.2%], P = 0.0035); rebleeding (18/47[38.3%] vs 8/49[16.3%], P = 0.0155). The results according to post-procedural clinical disease (regressive vs progressive change) were as follows: alive (14/21[66.7%] vs 8/75[10.7%], P&lt;0.0001); survival time (34.1±30.6[0.3-110] vs 3.6±4.0[0.07-22] months, P&lt;0.0001). The outcomes of endovascular management of PCBS can be improved by taking embolization as a prior way of treatment, performing endovascular intervention in slight clinical severity and aggressive management of the post-procedural clinical disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneurysms</subject><subject>Blood Vessel Prosthesis Implantation</subject><subject>Cardiovascular system</subject><subject>Care and treatment</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Carotid Artery Diseases - etiology</subject><subject>Carotid Artery Diseases - therapy</subject><subject>Carotid Artery, External - surgery</subject><subject>Consent</subject><subject>Disease control</subject><subject>Embolization</subject><subject>Embolization, Therapeutic - methods</subject><subject>Endovascular Procedures - methods</subject><subject>Female</subject><subject>Head &amp; neck cancer</subject><subject>Head and neck cancer</subject><subject>Head and Neck Neoplasms - complications</subject><subject>Hemostasis</subject><subject>Hemostatics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Implants</subject><subject>Lesions</subject><subject>Life assessment</subject><subject>Male</subject><subject>Management</subject><subject>Medicine</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Polyvinyl alcohol</subject><subject>Retrospective Studies</subject><subject>Stents</subject><subject>Surgical implants</subject><subject>Therapeutic embolization</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Vascular diseases</subject><subject>Vascular surgery</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAYhSMEYmPwDxBEQkJw0eJvOzdIoxpQaWiIAbeWEzutKyfubGewf49Ls6lBu0C-sGU_59jv61MUzyGYQ8zhu40fQq_cfOt7MwcQVwLBB8UxrDCaMQTww4P1UfEkxg0AFAvGHhdHiBFcMYyOi8VZr_21is3gVCi_qF6tTGf6VPq2_Opjmi1DUNqqZHS5UMEnq8sPzv_yQyovb3odfGeeFo9a5aJ5Ns4nxY-PZ98Xn2fnF5-Wi9PzWcMqlGbIaM2B5pxArghuAW0Zww0gxCDQIkFbTWtqoK5JfmktNIEY0yw1QDQUEnxSvNz7bp2Pcqw_SshznZwRXmViuSe0Vxu5DbZT4UZ6ZeXfDR9WUoVkG2ekqjmtBEGsJoIoKqoaAwwJrBgHWFCTvd6Ptw11Z3STmxKUm5hOT3q7lit_LQmtKOIsG7wZDYK_GkxMsrOxMc6p3vhh924ECIVMgIy--ge9v7qRWqlcgO1bn-9tdqbylGAgSAUpz9T8HioPbTrb5LC0Nu9PBG8ngswk8zut1BCjXF5--3_24ueUfX3Aro1yaR29G5L1fZyCZA82wccYTHvXZAjkLuu33ZC7rMsx61n24vCD7kS34cZ_ADVS9ms</recordid><startdate>20151006</startdate><enddate>20151006</enddate><creator>Chang, Feng-Chi</creator><creator>Luo, Chao-Bao</creator><creator>Lirng, Jiing-Feng</creator><creator>Lin, Chung-Jung</creator><creator>Lee, Han-Jui</creator><creator>Wu, Chih-Chun</creator><creator>Hung, Sheng-Che</creator><creator>Guo, Wan-Yuo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151006</creationdate><title>Endovascular Management of Post-Irradiated Carotid Blowout Syndrome</title><author>Chang, Feng-Chi ; Luo, Chao-Bao ; Lirng, Jiing-Feng ; Lin, Chung-Jung ; Lee, Han-Jui ; Wu, Chih-Chun ; Hung, Sheng-Che ; Guo, Wan-Yuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2edd70d77417a43f05f663c044e20f285fd5b5e1db4005b8d41335692e08c5143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aneurysms</topic><topic>Blood Vessel Prosthesis Implantation</topic><topic>Cardiovascular system</topic><topic>Care and treatment</topic><topic>Carotid arteries</topic><topic>Carotid artery</topic><topic>Carotid Artery Diseases - etiology</topic><topic>Carotid Artery Diseases - therapy</topic><topic>Carotid Artery, External - surgery</topic><topic>Consent</topic><topic>Disease control</topic><topic>Embolization</topic><topic>Embolization, Therapeutic - methods</topic><topic>Endovascular Procedures - methods</topic><topic>Female</topic><topic>Head &amp; neck cancer</topic><topic>Head and neck cancer</topic><topic>Head and Neck Neoplasms - complications</topic><topic>Hemostasis</topic><topic>Hemostatics</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Implants</topic><topic>Lesions</topic><topic>Life assessment</topic><topic>Male</topic><topic>Management</topic><topic>Medicine</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Polyvinyl alcohol</topic><topic>Retrospective Studies</topic><topic>Stents</topic><topic>Surgical implants</topic><topic>Therapeutic embolization</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Vascular diseases</topic><topic>Vascular surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Feng-Chi</creatorcontrib><creatorcontrib>Luo, Chao-Bao</creatorcontrib><creatorcontrib>Lirng, Jiing-Feng</creatorcontrib><creatorcontrib>Lin, Chung-Jung</creatorcontrib><creatorcontrib>Lee, Han-Jui</creatorcontrib><creatorcontrib>Wu, Chih-Chun</creatorcontrib><creatorcontrib>Hung, Sheng-Che</creatorcontrib><creatorcontrib>Guo, Wan-Yuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; 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Between 2000 and 2013, 96 patients with PCBS underwent endovascular management. The 40 patients with the pathological lesions located in the external carotid artery were classified as group 1 and were treated with embolization. The other 56 patients with the pathological lesions located in the trunk of the carotid artery were divided into 2 groups as follows: group 2A comprised the 38 patients treated with embolization, and group 2B comprised the 18 patients treated with stent-graft placement. Fisher's exact test was used to examine endovascular methods, clinical severities, and postprocedural clinical diseases as predictors of outcomes. Technical success and immediate hemostasis were achieved in all patients. The results according to endovascular methods (group 1 vs 2A vs 2B) were as follows: technical complication (1/40[2.5%] vs 9/38[23.7%] vs 9/18[50.0%], P = 0.0001); rebleeding (14/40[35.0%] vs 5/38[13.2%] vs 7/18[38.9%]), P = 0.0435). The results according to clinical severity (acute vs ongoing PCBS) were as follows: technical complication (15/47[31.9%] vs 4/49[8.2%], P = 0.0035); rebleeding (18/47[38.3%] vs 8/49[16.3%], P = 0.0155). The results according to post-procedural clinical disease (regressive vs progressive change) were as follows: alive (14/21[66.7%] vs 8/75[10.7%], P&lt;0.0001); survival time (34.1±30.6[0.3-110] vs 3.6±4.0[0.07-22] months, P&lt;0.0001). The outcomes of endovascular management of PCBS can be improved by taking embolization as a prior way of treatment, performing endovascular intervention in slight clinical severity and aggressive management of the post-procedural clinical disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26439632</pmid><doi>10.1371/journal.pone.0139821</doi><oa>free_for_read</oa></addata></record>
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source MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry
subjects Adult
Aged
Aged, 80 and over
Aneurysms
Blood Vessel Prosthesis Implantation
Cardiovascular system
Care and treatment
Carotid arteries
Carotid artery
Carotid Artery Diseases - etiology
Carotid Artery Diseases - therapy
Carotid Artery, External - surgery
Consent
Disease control
Embolization
Embolization, Therapeutic - methods
Endovascular Procedures - methods
Female
Head & neck cancer
Head and neck cancer
Head and Neck Neoplasms - complications
Hemostasis
Hemostatics
Hospitals
Humans
Implants
Lesions
Life assessment
Male
Management
Medicine
Methods
Middle Aged
Neck
Patient outcomes
Patients
Polyvinyl alcohol
Retrospective Studies
Stents
Surgical implants
Therapeutic embolization
Treatment Outcome
Tumors
Vascular diseases
Vascular surgery
title Endovascular Management of Post-Irradiated Carotid Blowout Syndrome
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