TGF-β1 Reduces miR-29a Expression to Promote Tumorigenicity and Metastasis of Cholangiocarcinoma by Targeting HDAC4

Transforming growth factor β1 (TGF-β1) and miRNAs play important roles in cholangiocarcinoma progression. In this study, miR-29a level was found significantly decreased in both cholangiocarcinoma tissues and tumor cell lines. TGF-β1 reduced miR-29a expression in tumor cell lines. Furthermore, anti-m...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0136703-e0136703
Hauptverfasser:	Wang, Huiling, Li, Caixia, Jian, Zhixiang, Ou, Yingliang, Ou, Jinrui
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biotechnology Blotting, Western Cancer therapies Cell cycle Cell growth Cell Line, Tumor Cell Movement - genetics Cell Movement - physiology Cell proliferation Cell Proliferation - genetics Cell Proliferation - physiology Cholangiocarcinoma Cholangiocarcinoma - genetics Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Gene expression Histone Deacetylases - genetics Histone Deacetylases - metabolism Hospitals Humans Leukemia Metastases Metastasis MicroRNAs MicroRNAs - genetics Neoplasm Metastasis - genetics Pathogenesis Repressor Proteins - genetics Repressor Proteins - metabolism Restoration Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects Surgery Therapeutic applications Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 Tumor cell lines Tumorigenicity Tumors Wound healing
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