Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25
Interleukin-23 (IL-23) is a conventional proinflammatory cytokine that plays a role in tumor progression by inducing inflammation in the tumor microenvironment. However, the role of IL-23 in thyroid cancer migration and invasion remains unclear. In the present study, we observed that the treatment w...
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| description | Interleukin-23 (IL-23) is a conventional proinflammatory cytokine that plays a role in tumor progression by inducing inflammation in the tumor microenvironment. However, the role of IL-23 in thyroid cancer migration and invasion remains unclear. In the present study, we observed that the treatment with IL-23, induced migration and invasion in human thyroid cancer cells. Additional data demonstrate that SOCS4 negatively regulates IL-23-mediated migration and invasion. On investigating the mechanisms involved in IL-23 mediated migration and invasion, we observed that miR-25 promotes the migration and invasion of thyroid cancer cells by directly binding to the 3'-UTR of SOCS4 that leads to the inhibition of SOCS4. In addition, we also demonstrated that IL-23 increases miR-25 expression levels, and overexpressed miR-25 is involved in IL-23-associated SOCS4 inhibition and cell migration and invasion. Together, our data suggest that IL-23 induces migration and invasion in thyroid cancer cells by mediating the miR-25/SOCS4 signaling pathway. |
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However, the role of IL-23 in thyroid cancer migration and invasion remains unclear. In the present study, we observed that the treatment with IL-23, induced migration and invasion in human thyroid cancer cells. Additional data demonstrate that SOCS4 negatively regulates IL-23-mediated migration and invasion. On investigating the mechanisms involved in IL-23 mediated migration and invasion, we observed that miR-25 promotes the migration and invasion of thyroid cancer cells by directly binding to the 3'-UTR of SOCS4 that leads to the inhibition of SOCS4. In addition, we also demonstrated that IL-23 increases miR-25 expression levels, and overexpressed miR-25 is involved in IL-23-associated SOCS4 inhibition and cell migration and invasion. Together, our data suggest that IL-23 induces migration and invasion in thyroid cancer cells by mediating the miR-25/SOCS4 signaling pathway.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0139456</identifier><identifier>PMID: 26437444</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>3' Untranslated Regions ; Adult ; Cancer ; Cancer metastasis ; Cell growth ; Cell migration ; Cell Movement - drug effects ; Colorectal cancer ; Cytokines ; Development and progression ; DNA, Neoplasm - metabolism ; Female ; Gastric cancer ; Gene Expression Regulation, Neoplastic - genetics ; Gene Expression Regulation, Neoplastic - physiology ; Genetic aspects ; Humans ; Inflammation ; Inhibition ; Interleukin ; Interleukin 23 ; Interleukin-23 - pharmacology ; Interleukins ; Liver cancer ; Lung cancer ; Male ; Metastasis ; MicroRNA ; MicroRNAs ; MicroRNAs - physiology ; Middle Aged ; miRNA ; Motility ; Neoplasm Invasiveness - physiopathology ; Otolaryngology ; Ovarian cancer ; Physiological aspects ; Proteins ; Real-Time Polymerase Chain Reaction ; Ribonucleic acid ; RNA ; RNA, Small Interfering - genetics ; Signal Transduction ; Stomach cancer ; Suppressor of Cytokine Signaling Proteins - biosynthesis ; Suppressor of Cytokine Signaling Proteins - genetics ; Suppressor of Cytokine Signaling Proteins - physiology ; Surgery ; Target recognition ; Thyroid ; Thyroid cancer ; Thyroid Neoplasms - pathology ; Tumor Cells, Cultured ; Tumors ; Up-Regulation</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0139456-e0139456</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Mei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Mei et al 2015 Mei et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-696132fde029ebc9874bad738ecd9305bf5f2714ff6a14a709bff3302c671da43</citedby><cites>FETCH-LOGICAL-c585t-696132fde029ebc9874bad738ecd9305bf5f2714ff6a14a709bff3302c671da43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593557/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593557/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26437444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mei, Zhidan</creatorcontrib><creatorcontrib>Chen, Shiming</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Xiao, Bokui</creatorcontrib><creatorcontrib>Li, Fen</creatorcontrib><creatorcontrib>Wang, Yongping</creatorcontrib><creatorcontrib>Tao, Zezhang</creatorcontrib><title>Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Interleukin-23 (IL-23) is a conventional proinflammatory cytokine that plays a role in tumor progression by inducing inflammation in the tumor microenvironment. However, the role of IL-23 in thyroid cancer migration and invasion remains unclear. In the present study, we observed that the treatment with IL-23, induced migration and invasion in human thyroid cancer cells. Additional data demonstrate that SOCS4 negatively regulates IL-23-mediated migration and invasion. On investigating the mechanisms involved in IL-23 mediated migration and invasion, we observed that miR-25 promotes the migration and invasion of thyroid cancer cells by directly binding to the 3'-UTR of SOCS4 that leads to the inhibition of SOCS4. In addition, we also demonstrated that IL-23 increases miR-25 expression levels, and overexpressed miR-25 is involved in IL-23-associated SOCS4 inhibition and cell migration and invasion. Together, our data suggest that IL-23 induces migration and invasion in thyroid cancer cells by mediating the miR-25/SOCS4 signaling pathway.</description><subject>3' Untranslated Regions</subject><subject>Adult</subject><subject>Cancer</subject><subject>Cancer metastasis</subject><subject>Cell growth</subject><subject>Cell migration</subject><subject>Cell Movement - drug effects</subject><subject>Colorectal cancer</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>DNA, Neoplasm - metabolism</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inhibition</subject><subject>Interleukin</subject><subject>Interleukin 23</subject><subject>Interleukin-23 - pharmacology</subject><subject>Interleukins</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - physiology</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Motility</subject><subject>Neoplasm Invasiveness - physiopathology</subject><subject>Otolaryngology</subject><subject>Ovarian cancer</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Small Interfering - genetics</subject><subject>Signal Transduction</subject><subject>Stomach cancer</subject><subject>Suppressor of Cytokine Signaling Proteins - biosynthesis</subject><subject>Suppressor of Cytokine Signaling Proteins - genetics</subject><subject>Suppressor of Cytokine Signaling Proteins - physiology</subject><subject>Surgery</subject><subject>Target recognition</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUl1v0zAUjRCIjcE_QBAJCfGS4m8nL0hVtUGlwSQ2ni3bsVuXzO7spKL_HrfNphbx5Ht9zz336xTFWwgmEHP4eRWG6GU3WQdvJgDihlD2rDiHDUYVQwA_P7LPilcprQCguGbsZXGGGMGcEHJe9HPfm9iZ4bfzFcLlldSuc73sTSrvltsYXFvOpNcmljPTdeV3t4iyd8GX0rfl3G9k2jlqm-2lU653flHe3sxuSXn5Zx1N2oc3TuZMHcPPH9MK0dfFCyu7ZN6M70Xx6-rybvatur75Op9NrytNa9pXrGEQI9sagBqjdFNzomTLcW1022BAlaUWcUisZRISyUGjrMUYIM04bCXBF8X7A--6C0mMC0sC8rwYTihAGTE_INogV2Id3b2MWxGkE_uPEBdCxt7pzgjTIMWU5o01gKBa1dIaDGF2GVLc1Jnry1htUPem1cb3UXYnpKcR75ZiETaC0AZTyjPBp5EghofBpF7cu6Tz1qU3YTj03XDG9tAP_0D_P92IWsg8gPM25Lp6RyqmBAPO-IHr4xFqaWTXL1Poht2V0ymQHID5kClFY59mg0DsNPnYhNhpUoyazGnvjvfylPQoQvwX04jdwA</recordid><startdate>20151005</startdate><enddate>20151005</enddate><creator>Mei, Zhidan</creator><creator>Chen, Shiming</creator><creator>Chen, Chen</creator><creator>Xiao, Bokui</creator><creator>Li, Fen</creator><creator>Wang, Yongping</creator><creator>Tao, Zezhang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151005</creationdate><title>Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25</title><author>Mei, Zhidan ; Chen, Shiming ; Chen, Chen ; Xiao, Bokui ; Li, Fen ; Wang, Yongping ; Tao, Zezhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-696132fde029ebc9874bad738ecd9305bf5f2714ff6a14a709bff3302c671da43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>3' Untranslated Regions</topic><topic>Adult</topic><topic>Cancer</topic><topic>Cancer metastasis</topic><topic>Cell growth</topic><topic>Cell migration</topic><topic>Cell Movement - drug effects</topic><topic>Colorectal cancer</topic><topic>Cytokines</topic><topic>Development and progression</topic><topic>DNA, Neoplasm - metabolism</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inhibition</topic><topic>Interleukin</topic><topic>Interleukin 23</topic><topic>Interleukin-23 - pharmacology</topic><topic>Interleukins</topic><topic>Liver cancer</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Metastasis</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - physiology</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>Motility</topic><topic>Neoplasm Invasiveness - physiopathology</topic><topic>Otolaryngology</topic><topic>Ovarian cancer</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Small Interfering - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mei, Zhidan</au><au>Chen, Shiming</au><au>Chen, Chen</au><au>Xiao, Bokui</au><au>Li, Fen</au><au>Wang, Yongping</au><au>Tao, Zezhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-10-05</date><risdate>2015</risdate><volume>10</volume><issue>10</issue><spage>e0139456</spage><epage>e0139456</epage><pages>e0139456-e0139456</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Interleukin-23 (IL-23) is a conventional proinflammatory cytokine that plays a role in tumor progression by inducing inflammation in the tumor microenvironment. However, the role of IL-23 in thyroid cancer migration and invasion remains unclear. In the present study, we observed that the treatment with IL-23, induced migration and invasion in human thyroid cancer cells. Additional data demonstrate that SOCS4 negatively regulates IL-23-mediated migration and invasion. On investigating the mechanisms involved in IL-23 mediated migration and invasion, we observed that miR-25 promotes the migration and invasion of thyroid cancer cells by directly binding to the 3'-UTR of SOCS4 that leads to the inhibition of SOCS4. In addition, we also demonstrated that IL-23 increases miR-25 expression levels, and overexpressed miR-25 is involved in IL-23-associated SOCS4 inhibition and cell migration and invasion. Together, our data suggest that IL-23 induces migration and invasion in thyroid cancer cells by mediating the miR-25/SOCS4 signaling pathway.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26437444</pmid><doi>10.1371/journal.pone.0139456</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 3' Untranslated Regions Adult Cancer Cancer metastasis Cell growth Cell migration Cell Movement - drug effects Colorectal cancer Cytokines Development and progression DNA, Neoplasm - metabolism Female Gastric cancer Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Genetic aspects Humans Inflammation Inhibition Interleukin Interleukin 23 Interleukin-23 - pharmacology Interleukins Liver cancer Lung cancer Male Metastasis MicroRNA MicroRNAs MicroRNAs - physiology Middle Aged miRNA Motility Neoplasm Invasiveness - physiopathology Otolaryngology Ovarian cancer Physiological aspects Proteins Real-Time Polymerase Chain Reaction Ribonucleic acid RNA RNA, Small Interfering - genetics Signal Transduction Stomach cancer Suppressor of Cytokine Signaling Proteins - biosynthesis Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - physiology Surgery Target recognition Thyroid Thyroid cancer Thyroid Neoplasms - pathology Tumor Cells, Cultured Tumors Up-Regulation |
| title | Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25 |
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