Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats

Obesity is associated with low-grade chronic inflammation. We hypothesized that Roux-en-Y gastric bypass (RYGB) surgery would reduce activation of the NLRP3 inflammasome in metabolically active adipose tissue (AT) of obese rats, and this change would be related to decreases in body weight and improv...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0139764-e0139764
Hauptverfasser:	Mocanu, Andreea Oana, Mulya, Anny, Huang, Hazel, Dan, Olivia, Shimizu, Hideharu, Batayyah, Esam, Brethauer, Stacy A, Dinischiotu, Anca, Kirwan, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adipocytes Adipose tissue Adipose Tissue - metabolism Animal tissues Animals Apoptosis Biochemistry Blood Glucose Body fat Body weight Care and treatment Carrier Proteins - metabolism Caspase Caspase 1 - metabolism Control methods Cytokines Diabetes Diabetes mellitus Diet Gastric Bypass Gastrointestinal surgery Gene expression Glucose Glucose metabolism Glucose tolerance Glucose Tolerance Test IL-1β Inflammasomes Inflammasomes - metabolism Inflammation Inflammation - metabolism Insulin resistance Interleukin-18 - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism Intervention Male Metabolism NLR Family, Pyrin Domain-Containing 3 Protein Obesity Obesity - metabolism Obesity - surgery Pathogenesis Patient outcomes Physiological aspects Prognosis Protein turnover Rats Rats, Sprague-Dawley Remission Risk factors Rodents Surgery Systematic review Tumor necrosis factor-TNF Weight control Women
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