Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen
Current evidences suggest that expression of Ki67, cyclooxygenase (COX), aromatase, adipokines, prostaglandins, free radicals, β-catenin and α-SMA might be involved in breast cancer pathogenesis. The main objective of this study was to compare expression/localization of these potential compounds in...
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| description | Current evidences suggest that expression of Ki67, cyclooxygenase (COX), aromatase, adipokines, prostaglandins, free radicals, β-catenin and α-SMA might be involved in breast cancer pathogenesis. The main objective of this study was to compare expression/localization of these potential compounds in breast cancer tissues with tissues collected adjacent to the tumor using immunohistochemistry and correlated with clinical pathology. The breast cancer specimens were collected from 30 women aged between 49 and 89 years who underwent breast surgery following cancer diagnosis. Expression levels of molecules by different stainings were graded as a score on a scale based upon staining intensity and proportion of positive cells/area or individually. AdipoR1, adiponectin, Ob-R, leptin, COX-1, COX-2, aromatase, PGF2α, F2-isoprostanes and α-SMA were localised on higher levels in the breast tissues adjacent to the tumor compared to tumor specimens when considering either score or staining area whereas COX-2 and AdipoR2 were found to be higher considering staining intensity and Ki67 on score level in the tumor tissue. There was no significant difference observed on β-catenin either on score nor on staining area and intensity between tissues adjacent to the tumor and tumor tissues. A positive correlation was found between COX-1 and COX-2 in the tumor tissues. In conclusion, these suggest that Ki67, COXs, aromatase, prostaglandin, free radicals, adipokines, β-catenin and α-SMA are involved in breast cancer. These further focus the need of examination of tissues adjacent to tumor, tumor itself and compare them with normal or benign breast tissues for a better understanding of breast cancer pathology and future evaluation of therapeutic benefit. |
| doi_str_mv | 10.1371/journal.pone.0138443 |
| format | Article |
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The main objective of this study was to compare expression/localization of these potential compounds in breast cancer tissues with tissues collected adjacent to the tumor using immunohistochemistry and correlated with clinical pathology. The breast cancer specimens were collected from 30 women aged between 49 and 89 years who underwent breast surgery following cancer diagnosis. Expression levels of molecules by different stainings were graded as a score on a scale based upon staining intensity and proportion of positive cells/area or individually. AdipoR1, adiponectin, Ob-R, leptin, COX-1, COX-2, aromatase, PGF2α, F2-isoprostanes and α-SMA were localised on higher levels in the breast tissues adjacent to the tumor compared to tumor specimens when considering either score or staining area whereas COX-2 and AdipoR2 were found to be higher considering staining intensity and Ki67 on score level in the tumor tissue. There was no significant difference observed on β-catenin either on score nor on staining area and intensity between tissues adjacent to the tumor and tumor tissues. A positive correlation was found between COX-1 and COX-2 in the tumor tissues. In conclusion, these suggest that Ki67, COXs, aromatase, prostaglandin, free radicals, adipokines, β-catenin and α-SMA are involved in breast cancer. These further focus the need of examination of tissues adjacent to tumor, tumor itself and compare them with normal or benign breast tissues for a better understanding of breast cancer pathology and future evaluation of therapeutic benefit.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0138443</identifier><identifier>PMID: 26431176</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipokines - metabolism ; Adiponectin ; Aged ; Aged, 80 and over ; Aromatase ; Aromatase - metabolism ; Biomarkers ; Breast cancer ; Breast Neoplasms - enzymology ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Breast surgery ; Cancer ; Care and treatment ; Cell growth ; Cell Proliferation ; Chemical compounds ; COX-2 inhibitors ; Cyclooxygenase-1 ; Cyclooxygenase-2 ; Development and progression ; Ethics ; Fatty acids ; Female ; Food and Nutrition ; Free radicals ; Genetic aspects ; Health risk assessment ; Humans ; Immunoglobulins ; Immunohistochemistry ; Inflammation ; Inflammation - metabolism ; Isoprostanes ; Kinases ; Leptin ; Life Sciences ; Lipid peroxidation ; Localization ; Medical research ; Metastasis ; Middle Aged ; Nutrition ; Obesity ; Oxidative stress ; Pathogenesis ; Pathology ; Patient outcomes ; Prostaglandin-Endoperoxide Synthases - metabolism ; Prostaglandins ; Risk factors ; Staining ; Surgery ; Tissues ; Tumors ; Womens health ; β-Catenin</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0138443-e0138443</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Basu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2015 Basu et al 2015 Basu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c763t-e34b0333a8f087dd77c20b48ead0b249308c18984a2a2d47d7a3e53d9fd39723</citedby><cites>FETCH-LOGICAL-c763t-e34b0333a8f087dd77c20b48ead0b249308c18984a2a2d47d7a3e53d9fd39723</cites><orcidid>0000-0002-2665-3822 ; 0000-0002-4279-5492</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592217/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592217/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26431176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01230714$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265677$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Coleman, William B.</contributor><creatorcontrib>Basu, Samar</creatorcontrib><creatorcontrib>Combe, Kristell</creatorcontrib><creatorcontrib>Kwiatkowski, Fabrice</creatorcontrib><creatorcontrib>Caldefie-Chézet, Florence</creatorcontrib><creatorcontrib>Penault-Llorca, Frédérique</creatorcontrib><creatorcontrib>Bignon, Yves-Jean</creatorcontrib><creatorcontrib>Vasson, Marie-Paule</creatorcontrib><title>Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Current evidences suggest that expression of Ki67, cyclooxygenase (COX), aromatase, adipokines, prostaglandins, free radicals, β-catenin and α-SMA might be involved in breast cancer pathogenesis. The main objective of this study was to compare expression/localization of these potential compounds in breast cancer tissues with tissues collected adjacent to the tumor using immunohistochemistry and correlated with clinical pathology. The breast cancer specimens were collected from 30 women aged between 49 and 89 years who underwent breast surgery following cancer diagnosis. Expression levels of molecules by different stainings were graded as a score on a scale based upon staining intensity and proportion of positive cells/area or individually. AdipoR1, adiponectin, Ob-R, leptin, COX-1, COX-2, aromatase, PGF2α, F2-isoprostanes and α-SMA were localised on higher levels in the breast tissues adjacent to the tumor compared to tumor specimens when considering either score or staining area whereas COX-2 and AdipoR2 were found to be higher considering staining intensity and Ki67 on score level in the tumor tissue. There was no significant difference observed on β-catenin either on score nor on staining area and intensity between tissues adjacent to the tumor and tumor tissues. A positive correlation was found between COX-1 and COX-2 in the tumor tissues. In conclusion, these suggest that Ki67, COXs, aromatase, prostaglandin, free radicals, adipokines, β-catenin and α-SMA are involved in breast cancer. These further focus the need of examination of tissues adjacent to tumor, tumor itself and compare them with normal or benign breast tissues for a better understanding of breast cancer pathology and future evaluation of therapeutic benefit.</description><subject>Adipokines - metabolism</subject><subject>Adiponectin</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aromatase</subject><subject>Aromatase - metabolism</subject><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - enzymology</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast surgery</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cell growth</subject><subject>Cell Proliferation</subject><subject>Chemical compounds</subject><subject>COX-2 inhibitors</subject><subject>Cyclooxygenase-1</subject><subject>Cyclooxygenase-2</subject><subject>Development and progression</subject><subject>Ethics</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Food and Nutrition</subject><subject>Free radicals</subject><subject>Genetic aspects</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Inflammation - 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Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basu, Samar</au><au>Combe, Kristell</au><au>Kwiatkowski, Fabrice</au><au>Caldefie-Chézet, Florence</au><au>Penault-Llorca, Frédérique</au><au>Bignon, Yves-Jean</au><au>Vasson, Marie-Paule</au><au>Coleman, William B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-10-02</date><risdate>2015</risdate><volume>10</volume><issue>10</issue><spage>e0138443</spage><epage>e0138443</epage><pages>e0138443-e0138443</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Current evidences suggest that expression of Ki67, cyclooxygenase (COX), aromatase, adipokines, prostaglandins, free radicals, β-catenin and α-SMA might be involved in breast cancer pathogenesis. The main objective of this study was to compare expression/localization of these potential compounds in breast cancer tissues with tissues collected adjacent to the tumor using immunohistochemistry and correlated with clinical pathology. The breast cancer specimens were collected from 30 women aged between 49 and 89 years who underwent breast surgery following cancer diagnosis. Expression levels of molecules by different stainings were graded as a score on a scale based upon staining intensity and proportion of positive cells/area or individually. AdipoR1, adiponectin, Ob-R, leptin, COX-1, COX-2, aromatase, PGF2α, F2-isoprostanes and α-SMA were localised on higher levels in the breast tissues adjacent to the tumor compared to tumor specimens when considering either score or staining area whereas COX-2 and AdipoR2 were found to be higher considering staining intensity and Ki67 on score level in the tumor tissue. There was no significant difference observed on β-catenin either on score nor on staining area and intensity between tissues adjacent to the tumor and tumor tissues. A positive correlation was found between COX-1 and COX-2 in the tumor tissues. In conclusion, these suggest that Ki67, COXs, aromatase, prostaglandin, free radicals, adipokines, β-catenin and α-SMA are involved in breast cancer. These further focus the need of examination of tissues adjacent to tumor, tumor itself and compare them with normal or benign breast tissues for a better understanding of breast cancer pathology and future evaluation of therapeutic benefit.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26431176</pmid><doi>10.1371/journal.pone.0138443</doi><orcidid>https://orcid.org/0000-0002-2665-3822</orcidid><orcidid>https://orcid.org/0000-0002-4279-5492</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-10, Vol.10 (10), p.e0138443-e0138443 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1719373843 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adipokines - metabolism Adiponectin Aged Aged, 80 and over Aromatase Aromatase - metabolism Biomarkers Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast surgery Cancer Care and treatment Cell growth Cell Proliferation Chemical compounds COX-2 inhibitors Cyclooxygenase-1 Cyclooxygenase-2 Development and progression Ethics Fatty acids Female Food and Nutrition Free radicals Genetic aspects Health risk assessment Humans Immunoglobulins Immunohistochemistry Inflammation Inflammation - metabolism Isoprostanes Kinases Leptin Life Sciences Lipid peroxidation Localization Medical research Metastasis Middle Aged Nutrition Obesity Oxidative stress Pathogenesis Pathology Patient outcomes Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins Risk factors Staining Surgery Tissues Tumors Womens health β-Catenin |
| title | Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen |
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