Characterization of Acute and Chronic Hepatitis B Virus Genotypes in Canada
The prevalence and distribution of hepatitis B virus (HBV) genotypes in Canada is not known. Genotypic analysis may contribute to a better understanding of HBV strain distribution and transmission risk. HBV surface antigen (HBsAg) positive samples of acute (n = 152) and chronic (n = 1533) HBV submit...
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| description | The prevalence and distribution of hepatitis B virus (HBV) genotypes in Canada is not known. Genotypic analysis may contribute to a better understanding of HBV strain distribution and transmission risk.
HBV surface antigen (HBsAg) positive samples of acute (n = 152) and chronic (n = 1533) HBV submitted for strain analysis or reference genotype testing between 2006 and 2012 were analyzed. The HBsAg coding region was amplified to determine the HBV genotype by INNO-LiPA assay or sequence analysis. Single and multivariate analyses were used to describe genotypes' associations with known demographic and behavioral risk factors for 126 linked cases of acute HBV.
Nine genotypes were detected (A to I), including mixed infections. Genotype C (HBV/C) dominated within chronic infections while HBV/D and A prevailed among acute HBV cases. History of incarceration and residing with a chronic HBV carrier or injection drug user were the most frequently reported risks for acute HBV infection. Over time, HBV/A increased among both acute and chronic infections, and HBV/C and HBV/D decreased among chronic infections.
Chronic and acute HBV genotypes in Canada differ in the relative distribution and their associations with known risk factors, suggesting different routes of transmission and clinical progression of infection. |
| doi_str_mv | 10.1371/journal.pone.0136074 |
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HBV surface antigen (HBsAg) positive samples of acute (n = 152) and chronic (n = 1533) HBV submitted for strain analysis or reference genotype testing between 2006 and 2012 were analyzed. The HBsAg coding region was amplified to determine the HBV genotype by INNO-LiPA assay or sequence analysis. Single and multivariate analyses were used to describe genotypes' associations with known demographic and behavioral risk factors for 126 linked cases of acute HBV.
Nine genotypes were detected (A to I), including mixed infections. Genotype C (HBV/C) dominated within chronic infections while HBV/D and A prevailed among acute HBV cases. History of incarceration and residing with a chronic HBV carrier or injection drug user were the most frequently reported risks for acute HBV infection. Over time, HBV/A increased among both acute and chronic infections, and HBV/C and HBV/D decreased among chronic infections.
Chronic and acute HBV genotypes in Canada differ in the relative distribution and their associations with known risk factors, suggesting different routes of transmission and clinical progression of infection.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0136074</identifier><identifier>PMID: 26406309</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute Disease ; Antigens ; Canada - epidemiology ; Chronic illnesses ; Chronic infection ; Consent ; Demographics ; Disease control ; Epidemiology ; Female ; Genotype ; Genotype & phenotype ; Genotypes ; Health risk assessment ; Health risks ; Health surveillance ; Hepatitis ; Hepatitis B ; Hepatitis B surface antigen ; Hepatitis B Surface Antigens - genetics ; Hepatitis B virus - genetics ; Hepatitis B, Chronic - epidemiology ; Hepatitis B, Chronic - genetics ; Hepatitis B, Chronic - prevention & control ; Hepatology ; Humans ; Immunization ; Infections ; Laboratories ; Male ; Mutation ; Public health ; Risk analysis ; Risk factors ; Risk taking ; Strain analysis ; Strain distribution ; Vaccination ; Viruses</subject><ispartof>PloS one, 2015-09, Vol.10 (9), p.e0136074-e0136074</ispartof><rights>2015 Osiowy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Osiowy et al 2015 Osiowy et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-9031114cf47af81ffad45bd157b9324bfb3e1ecf350ea124e0ec120f76da491f3</citedby><cites>FETCH-LOGICAL-c526t-9031114cf47af81ffad45bd157b9324bfb3e1ecf350ea124e0ec120f76da491f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583310/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583310/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26406309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Khudyakov, Yury E</contributor><creatorcontrib>Osiowy, Carla</creatorcontrib><creatorcontrib>Giles, Elizabeth</creatorcontrib><creatorcontrib>Trubnikov, Max</creatorcontrib><creatorcontrib>Choudhri, Yogesh</creatorcontrib><creatorcontrib>Andonov, Anton</creatorcontrib><title>Characterization of Acute and Chronic Hepatitis B Virus Genotypes in Canada</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The prevalence and distribution of hepatitis B virus (HBV) genotypes in Canada is not known. Genotypic analysis may contribute to a better understanding of HBV strain distribution and transmission risk.
HBV surface antigen (HBsAg) positive samples of acute (n = 152) and chronic (n = 1533) HBV submitted for strain analysis or reference genotype testing between 2006 and 2012 were analyzed. The HBsAg coding region was amplified to determine the HBV genotype by INNO-LiPA assay or sequence analysis. Single and multivariate analyses were used to describe genotypes' associations with known demographic and behavioral risk factors for 126 linked cases of acute HBV.
Nine genotypes were detected (A to I), including mixed infections. Genotype C (HBV/C) dominated within chronic infections while HBV/D and A prevailed among acute HBV cases. History of incarceration and residing with a chronic HBV carrier or injection drug user were the most frequently reported risks for acute HBV infection. Over time, HBV/A increased among both acute and chronic infections, and HBV/C and HBV/D decreased among chronic infections.
Chronic and acute HBV genotypes in Canada differ in the relative distribution and their associations with known risk factors, suggesting different routes of transmission and clinical progression of infection.</description><subject>Acute Disease</subject><subject>Antigens</subject><subject>Canada - epidemiology</subject><subject>Chronic illnesses</subject><subject>Chronic infection</subject><subject>Consent</subject><subject>Demographics</subject><subject>Disease control</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Health surveillance</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B surface antigen</subject><subject>Hepatitis B Surface Antigens - genetics</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B, Chronic - epidemiology</subject><subject>Hepatitis B, Chronic - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osiowy, Carla</au><au>Giles, Elizabeth</au><au>Trubnikov, Max</au><au>Choudhri, Yogesh</au><au>Andonov, Anton</au><au>Khudyakov, Yury E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Acute and Chronic Hepatitis B Virus Genotypes in Canada</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-09-25</date><risdate>2015</risdate><volume>10</volume><issue>9</issue><spage>e0136074</spage><epage>e0136074</epage><pages>e0136074-e0136074</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The prevalence and distribution of hepatitis B virus (HBV) genotypes in Canada is not known. Genotypic analysis may contribute to a better understanding of HBV strain distribution and transmission risk.
HBV surface antigen (HBsAg) positive samples of acute (n = 152) and chronic (n = 1533) HBV submitted for strain analysis or reference genotype testing between 2006 and 2012 were analyzed. The HBsAg coding region was amplified to determine the HBV genotype by INNO-LiPA assay or sequence analysis. Single and multivariate analyses were used to describe genotypes' associations with known demographic and behavioral risk factors for 126 linked cases of acute HBV.
Nine genotypes were detected (A to I), including mixed infections. Genotype C (HBV/C) dominated within chronic infections while HBV/D and A prevailed among acute HBV cases. History of incarceration and residing with a chronic HBV carrier or injection drug user were the most frequently reported risks for acute HBV infection. Over time, HBV/A increased among both acute and chronic infections, and HBV/C and HBV/D decreased among chronic infections.
Chronic and acute HBV genotypes in Canada differ in the relative distribution and their associations with known risk factors, suggesting different routes of transmission and clinical progression of infection.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26406309</pmid><doi>10.1371/journal.pone.0136074</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Antigens Canada - epidemiology Chronic illnesses Chronic infection Consent Demographics Disease control Epidemiology Female Genotype Genotype & phenotype Genotypes Health risk assessment Health risks Health surveillance Hepatitis Hepatitis B Hepatitis B surface antigen Hepatitis B Surface Antigens - genetics Hepatitis B virus - genetics Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - genetics Hepatitis B, Chronic - prevention & control Hepatology Humans Immunization Infections Laboratories Male Mutation Public health Risk analysis Risk factors Risk taking Strain analysis Strain distribution Vaccination Viruses |
| title | Characterization of Acute and Chronic Hepatitis B Virus Genotypes in Canada |
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