Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination

Mesenchymal stem cells (MSCs) are pleiotropic cells with potential therapeutic benefits for a wide range of diseases. Because of their immunomodulatory properties they have been utilized to treat autoimmune diseases such as multiple sclerosis (MS), which is characterized by demyelination. The microe...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0139008-e0139008
Hauptverfasser:	Glenn, Justin D, Smith, Matthew D, Kirby, Leslie A, Baxi, Emily G, Whartenby, Katharine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animal models Animals Apoptosis Autoimmune diseases Biological effects Bone marrow Brain Care and treatment CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell Death Cell Proliferation Central nervous system Corpus Callosum - pathology Cuprizone Cytokines - biosynthesis Demyelinating diseases Demyelinating Diseases - chemically induced Demyelinating Diseases - immunology Demyelinating Diseases - pathology Demyelinating Diseases - therapy Demyelination Disease Effector cells Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - therapy Experimental allergic encephalomyelitis Female Genetic aspects Helper cells Immunomodulation Laboratories Lymphocyte Subsets - immunology Lymphocytes Lymphocytes T Medical treatment Medicine Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Mice, Inbred C57BL Microenvironments Multiple sclerosis Myelin Myelin-Oligodendrocyte Glycoprotein - immunology Nervous system Neurology Oligodendroglia - pathology Peptide Fragments - immunology Phenotypes Physiological aspects Rheumatoid arthritis Rodents Stem cell transplantation Stem cells Transplants & implants γ-Interferon
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