The Role of Dietary Extra Virgin Olive Oil and Corn Oil on the Alteration of Epigenetic Patterns in the Rat DMBA-Induced Breast Cancer Model

Disruption of epigenetic patterns is a major change occurring in all types of cancers. Such alterations are characterized by global DNA hypomethylation, gene-promoter hypermethylation and aberrant histone modifications, and may be modified by environment. Nutritional factors, and especially dietary...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0138980-e0138980
Hauptverfasser:	Rodríguez-Miguel, Cristina, Moral, Raquel, Escrich, Raquel, Vela, Elena, Solanas, Montserrat, Escrich, Eduard
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene Aging Animals Anthracene Bisulfite Breast cancer Cancer Care and treatment Corn Corn oil Corn Oil - pharmacology Deoxyribonucleic acid Diet Diet, High-Fat Disease Models, Animal DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA Methylation - drug effects DNA methyltransferase DNMT1 protein Enzymatic activity Epigenesis, Genetic - drug effects Epigenetic inheritance Epigenetics Etiology Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genetic transformation Health aspects High fat diet Histones - metabolism Lipids Mammary gland Mammary glands Mammary Neoplasms, Animal - chemically induced Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - pathology Oils & fats Olive oil Olive Oil - pharmacology Promoter Regions, Genetic - genetics Protein Processing, Post-Translational - drug effects Protein Processing, Post-Translational - genetics Puberty Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Tissue inhibitor of metalloproteinase 3 Tissue Inhibitor of Metalloproteinase-3 - genetics Tissue Inhibitor of Metalloproteinase-3 - metabolism Transformation Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Vegetables Weaning
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